An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 113

Institut Curie, Paris, France

Elucidating the biological role of chromatin in genome stability

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The overall objective of our team is to determine how chromosome structure and function affect genome stability. Specifically, we aim to understand how chromatin is integrated into the genome stability networks and to decipher the interconnections between chromatin regulators and genome stability factors during repair of DNA damage and DNA replication. Using budding yeast as a model system we approach our question with a combination of yeast functional genomics coupled with bio-computational analysis and biochemical assays. Our goal is to map the functional networks of chromatin in genome stability, providing insight into the dynamic role of chromatin in DNA metabolism and advancing our understanding of the cellular response to DNA damage.

List of people involved:

  • Laura Roseaulin
  • Petra Kaferle
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Latest publications

INO80 Chromatin Remodeler Facilitates Release of RNA Polymerase II from Chromatin for Ubiquitin-Mediated Proteasomal Degradation.

26656161 – 2015-12-15
Mol Cell 2015 Dec 3;60(5):784-796
Lafon A, Taranum S, Pietrocola F, Dingli F, Loew D, Brahma S, Bartholomew B, Papamichos-Chronakis M

DNA repair choice defines a common pathway for recruitment of chromatin regulators.

23811932 – 2013-07-03
Nat Commun 2013 Jun 28;4:2084
Bennett G, Papamichos-Chronakis M, Peterson CL

Chromatin and the genome integrity network.

23247436 – 2012-12-19
Nat Rev Genet 2012 Dec 18;14(1):62-75
Papamichos-Chronakis M, Peterson CLView all their publications