An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 89

Institut de Génétique Humaine, Montpellier (France)

The role of epigenetics in cell-specific alternative splicing programming

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Alternative splicing is a key mechanism of cell identity that produces cell-type-specific protein variants from ubiquitously expressed genes. Misregulation of the cell-specific splicing programs impairs cellular function and can lead to disease, including cancer. Traditionally, alternative splicing has been thought to be regulated mainly at the RNA level by combinatorial recruitment of splicing factors to specific RNA-binding sites. However, epigenetic modifications, such as DNA methylation and histone modifications, chromatin conformation and non-coding RNAs have recently been shown to play a role in alternative splicing regulation. My lab will address the role of epigenetics in establishing and maintaining a cell-specific alternative splicing program and will depict the molecular mechanisms driving this control both at a gene-specific and genome-wide level.

People involved:

  • Laetitia Michelle, PhD – postdoc, molecular biologist
  • Eneritz Agirre, PhD – postdoc, computer biologist
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Latest publications

A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature.

25849144 – 2015-04-08
Nat Struct Mol Biol 2015 May;22(5):370-6
Gonzalez I, Munita R, Agirre E, Dittmer TA, Gysling K, Misteli T, Luco RF

The non-coding genome: a universe in expansion for fine-tuning the coding world.

24267819 – 2013-11-26
Genome Biol 2013 Nov 22;14(11):314
Luco RFView all their publications


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