An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 102

Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch, France

Epigenetics and cell fate in early mammalian development

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We use the mouse embryo as a model system to understand the epigenetic mechanisms behind cellular potency and cell fate. The dynamic interplay and the possible causal relationship between epigenetic modifiers and the transcription factors responsible for lineage allocation are not known. In order to understand how lineage commitment is progressively determined during early embryogenesis it is essential to understand both, the dynamic epigenetic properties of the embryo as well as the dynamics of activation of the transcription factors involved in lineage allocation. Our aim is to generate a mathematical model that will predict cell fate decisions driven by epigenetic modifiers and to establish their interrelation in the activation of key transcription factors.

People involved:

  • Adam Burton
  • Andre Eid
  • Joanna Jachowicz
  • Yusuke Miyanari
FaLang translation system by Faboba

Latest publications

Voices of biotech.

26963549 – 2016-03-11
Nat Biotechnol 2016 Mar 10;34(3):270-5
Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T

Regulation of Reprogramming and Cellular Plasticity through Histone Exchange and Histone Variant Incorporation.

26582788 – 2015-11-20
Cold Spring Harb Symp Quant Biol 2015 Nov 18;
Gaume X, Torres-Padilla ME

Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly.

26237512 – 2015-08-04
Nat Struct Mol Biol 2015 Aug 3;
Ishiuchi T, Enriquez-Gasca R, Mizutani E, Bošković A, Ziegler-Birling C, Rodriguez-Terrones D, Wakayama T, Vaquerizas JM, Torres-Padilla MEView all their publications

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