Advancing Epigenetics Towards Systems Biology

Biola Maria Javierre

Josep Carreras Leukemia Research Institute, Barcelona, Spain

3D chromatin organization in normal and malignant hematopoiesis

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biola maria javierre

Every cell in our body has about 2 metres of linear DNA containing the genes that shape our being. This DNA, which is the same in every cell, is not-randomly packed into the nucleus, and the manner in which it is wrapped plays a fundamental role in regulating genome function. Chromatin interactions are crucial for cellular health and errors in these interactions give rise to the development of a broad range of diseases including blood cancer. The investigation of these altered 3D structures can help us to improve our knowledge of the tumour process, providing new opportunities for the development of novel treatment approaches and diagnostic strategies. Our group combines cutting-edge experimental and bioinformatics approaches to understand the specific 3D chromatin organization of blood cells and its alteration in hematological cancers. Our long-term goal is to keep taking steps forwards in the fight against cancer. We will be unstoppable until we cure it.