Advancing Epigenetics Towards Systems Biology

Miguel Branco

Blizard Institute, QMUL

Epigenetic regulation of transposable elements

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miguel branco
Our group is interested in the epigenetic regulation of transposable elements and its impact on genome function. Almost half of the human genome is made up of transposons, and a proportion of these remain active and mobile. Therefore, their transcription needs to be tightly controlled to prevent mutagenic events. On the other hand, transposons have helped to drive genome evolution, often contributing with gene regulatory elements, amongst other genetic components. Our lab uses epigenomic approaches and molecular biology tools to investigate the mechanisms involved in these two seemingly opposing facets of transposon biology. We aim to elucidate the functional roles that transposable elements play in the contexts of development, health and disease.