Advancing Epigenetics Towards Systems Biology

Sophie Polo

Epigenetics & Cell Fate Centre, CNRS/Paris Diderot University

Epigenome integrity

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sophie polo

DNA damage challenges not only genome stability but also the integrity of its organization with histone proteins into chromatin, which is central to genome functions and cell identity. Understanding how the original chromatin architecture and the information that it conveys are preserved or altered after genotoxic stress is thus of fundamental importance. To address this question, we study chromatin dynamics in response to DNA damage in mammalian cells. Our research focuses on identifying the molecular players that control histone dynamics, modifications and alterations in higher-order chromatin structure and function in response to genotoxic stress. By combining molecular and cellular approaches with cutting-edge imaging techniques, we aim at understanding how genome and epigenome maintenance are coordinated.