Organic Synthesis and Cell Biology
We study cell biology at the molecular level using an integrated strategy, combining molecular biology with synthetic organic chemistry. Our interest includes the development of unbiased protocols to identify genomic targets of small molecules using DNA sequencing technologies. We investigate the changes of the epigenetic landscape upon treatment with genotoxic agents, and determine to what extend different epigenetic states can determine and predict treatment outcome. We have also discovered that iron homeostasis is a druggable network in cancer stem cells. We are now investigating the endocytotic processes of cellular iron import and export during cancer development, and improve our existing molecules with the aim to tackle relapse and metastasis formation in cancer.