Advancing Epigenetics Towards Systems Biology

Antoine Coulon

CNRS/Institut Curie

Genome functions in space and time

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antoine coulon

Our group studies the two-way relationship between the spatio-temporal dynamics of the genome and the coordinated regulation of its expression, through an approach at the interface between physics, computer science and biology. We combine microscopy techniques for observing transcriptional processes at the single-molecule level (individual RNAs and proteins) with data analysis and physical modeling approaches in order to study how genes coordinate in space and in time in a single nucleus. We are interested in topics spanning a broad range of scales – including compartmentalization of the genome in the nuclear space, enhancer-gene communication and the effect of supercoiling on the local conformation of chromosomes.