Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Christoph Bock41 Publications.


Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.

Nat Chem Biol 2016 May 9;

Sdelci S, Lardeau CH, Tallant C, Klepsch F, Klaiber B, Bennett J, Rathert P, Schuster M, Penz T, Fedorov O, Superti-Furga G, Bock C, Zuber J, Huber KV, Knapp S, Müller S, Kubicek S

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A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN.

Cell Rep 2016 Apr 14;

Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang SC, Schuster M, Breitwieser FP, Pichlmair A, El-Khamisy SF, Bock C, Kralovics R, Colinge J, Bennett KL, Loizou JI

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Familial early-onset dementia with complex neuropathologic phenotype and genomic background.

Neurobiol Aging 2016 Jun;42:199-204

Alexander J, Kalev O, Mehrabian S, Traykov L, Raycheva M, Kanakis D, Drineas P, Lutz MI, Ströbel T, Penz T, Schuster M, Bock C, Ferrer I, Paschou P, Kovacs GG

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DeepBlue epigenomic data server: programmatic data retrieval and analysis of epigenome region sets.

Nucleic Acids Res 2016 Apr 15;

Albrecht F, List M, Bock C, Lengauer T

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Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time.

Biotechnol Bioeng 2016 Apr 12;

Feichtinger J, Hernández I, Fischer C, Hanscho M, Auer N, Hackl M, Jadhav V, Baumann M, Krempl PM, Schmidl C, Farlik M, Schuster M, Merkel A, Sommer A, Heath S, Rico D, Bock C, Thallinger GG, Borth N

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Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types.

EMBO Rep 2015 Dec 21;

Li J, Klughammer J, Farlik M, Penz T, Spittler A, Barbieux C, Berishvili E, Bock C, Kubicek S

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Differential DNA Methylation Analysis without a Reference Genome.

Cell Rep 2015 Dec 22;13(11):2621-33

Klughammer J, Datlinger P, Printz D, Sheffield NC, Farlik M, Hadler J, Fritsch G, Bock C

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LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor.

Bioinformatics 2015 Oct 27;

Sheffield NC, Bock C

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Whole exome sequencing identifies novel MPL and JAK2 mutations in triple negative myeloproliferative neoplasms.

Blood 2015 Sep 30;

Milosevic Feenstra JD, Nivarthi H, Gisslinger H, Leroy E, Rumi E, Chachoua I, Bagienski K, Kubesova B, Pietra D, Gisslinger B, Milanesi C, Jäger R, Chen D, Berg T, Schalling M, Schuster M, Bock C, Constantinescu SN, Cazzola M, Kralovics R

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ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors.

Nat Methods 2015 Oct;12(10):963-5

Schmidl C, Rendeiro AF, Sheffield NC, Bock C

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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