Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications


Information is retrieved from

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Group Leader:
Fred Van Leeuwen19 Publications.

2015

Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.

Sci Rep 2015 May 12;5:9824

Stulemeijer IJ, De Vos D, van Harten K, Joshi OK, Blomberg O, van Welsem T, Terweij M, Vlaming H, de Graaf EL, Altelaar AF, Bakker BM, van Leeuwen F

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2014

Yeast PP4 Interacts with ATR Homolog Ddc2-Mec1 and Regulates Checkpoint Signaling.

Mol Cell 2014 Dec 17;

Hustedt N, Seeber A, Sack R, Tsai-Pflugfelder M, Bhullar B, Vlaming H, van Leeuwen F, Guénolé A, van Attikum H, Srivas R, Ideker T, Shimada K, Gasser SM

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N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging.

J Cell Sci 2014 Nov 20;

van Deventer S, Menendez-Benito V, van Leeuwen F, Neefjes J

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Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo.

EMBO Rep 2014 Nov;15(11):1220-1221

Vlaming H, van Welsem T, de Graaf EL, Ontoso D, Altelaar AM, San-Segundo PA, Heck AJ, van Leeuwen F

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Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo.

EMBO Rep 2014 Aug 20;

Vlaming H, van Welsem T, de Graaf EL, Ontoso D, Altelaar AM, San-Segundo PA, Heck AJ, van Leeuwen F

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2013

A UV-Induced Genetic Network Links the RSC Complex to Nucleotide Excision Repair and Shows Dose-Dependent Rewiring.

Cell Rep 2013 Dec 26;5(6):1714-24

Srivas R, Costelloe T, Carvunis AR, Sarkar S, Malta E, Sun SM, Pool M, Licon K, van Welsem T, van Leeuwen F, McHugh PJ, van Attikum H, Ideker T

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A network model of the molecular organization of chromatin in Drosophila.

Mol Cell 2013 Feb 21;49(4):759-71

van Bemmel JG, Filion GJ, Rosado A, Talhout W, de Haas M, van Welsem T, van Leeuwen F, van Steensel B

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Dot1-Dependent Histone H3K79 Methylation Promotes Activation of the Mek1 Meiotic Checkpoint Effector Kinase by Regulating the Hop1 Adaptor.

PLoS Genet 2013 Jan;9(1):e1003262

Ontoso D, Acosta I, van Leeuwen F, Freire R, San-Segundo PA

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2012

Spatiotemporal analysis of organelle and macromolecular complex inheritance.

Proc Natl Acad Sci U S A 2012 Dec 17;

Menendez-Benito V, van Deventer SJ, Jimenez-Garcia V, Roy-Luzarraga M, van Leeuwen F, Neefjes J

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An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.

EMBO J 2012 Jul 20;

Hegnauer AM, Hustedt N, Shimada K, Pike BL, Vogel M, Amsler P, Rubin SM, van Leeuwen F, Guénolé A, van Attikum H, Thomä NH, Gasser SM

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Latest publications

2017-06-27

The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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2017-05-26

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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2017-04-30

The impact of rare and low-frequency genetic variants in common disease.

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