Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

Information is retrieved from


Back to the index page

Group Leader:
Sarah Teichmann39 Publications.


Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation.

Cell Stem Cell 2015 Oct 1;17(4):471-85

Kolodziejczyk AA, Kim JK, Tsang JC, Ilicic T, Henriksson J, Natarajan KN, Tuck AC, Gao X, Bühler M, Liu P, Marioni JC, Teichmann SA

View on PubMed

Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells.

Genome Biol 2015 Sep 21;16(1):178

Tsang JC, Yu Y, Burke S, Buettner F, Wang C, Kolodziejczyk AA, Teichmann SA, Lu L, Liu P

View on PubMed

Computational assignment of cell-cycle stage from single-cell transcriptome data.

Methods 2015 Sep 1;85:54-61

Scialdone A, Natarajan KN, Saraiva LR, Proserpio V, Teichmann SA, Stegle O, Marioni JC, Buettner F

View on PubMed

The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding.

PLoS Genet 2015 May;11(5):e1005251

Xie X, Stubbington MJ, Nissen JK, Andersen KG, Hebenstreit D, Teichmann SA, Betz AG

View on PubMed

The technology and biology of single-cell RNA sequencing.

Mol Cell 2015 May 21;58(4):610-20

Kolodziejczyk AA, Kim JK, Svensson V, Marioni JC, Teichmann SA

View on PubMed

An atlas of mouse CD4(+) T cell transcriptomes.

Biol Direct 2015 Apr 3;10:14

Stubbington MJ, Mahata B, Svensson V, Deonarine A, Nissen JK, Betz AG, Teichmann SA

View on PubMed

Structural and evolutionary versatility in protein complexes with uneven stoichiometry.

Nat Commun 2015 Mar 16;6:6394

Marsh JA, Rees HA, Ahnert SE, Teichmann SA

View on PubMed

Computational and analytical challenges in single-cell transcriptomics.

Nat Rev Genet 2015 Mar;16(3):133-45

Stegle O, Teichmann SA, Marioni JC

View on PubMed

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells.

Nat Biotechnol 2015 Jan 19;

Buettner F, Natarajan KN, Casale FP, Proserpio V, Scialdone A, Theis FJ, Teichmann SA, Marioni JC, Stegle O

View on PubMed


Evolution of oligomeric state through allosteric pathways that mimic ligand binding.

Science 2014 Dec 19;346(6216):1254346

Perica T, Kondo Y, Tiwari SP, McLaughlin SH, Kemplen KR, Zhang X, Steward A, Reuter N, Clarke J, Teichmann SA

View on PubMed

Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

Read more

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

Read more

The impact of rare and low-frequency genetic variants in common disease.

Read more