Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications


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Group Leader:
Sarah Teichmann39 Publications.

2015

Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation.

Cell Stem Cell 2015 Oct 1;17(4):471-85

Kolodziejczyk AA, Kim JK, Tsang JC, Ilicic T, Henriksson J, Natarajan KN, Tuck AC, Gao X, Bühler M, Liu P, Marioni JC, Teichmann SA

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Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells.

Genome Biol 2015 Sep 21;16(1):178

Tsang JC, Yu Y, Burke S, Buettner F, Wang C, Kolodziejczyk AA, Teichmann SA, Lu L, Liu P

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Computational assignment of cell-cycle stage from single-cell transcriptome data.

Methods 2015 Sep 1;85:54-61

Scialdone A, Natarajan KN, Saraiva LR, Proserpio V, Teichmann SA, Stegle O, Marioni JC, Buettner F

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The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding.

PLoS Genet 2015 May;11(5):e1005251

Xie X, Stubbington MJ, Nissen JK, Andersen KG, Hebenstreit D, Teichmann SA, Betz AG

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The technology and biology of single-cell RNA sequencing.

Mol Cell 2015 May 21;58(4):610-20

Kolodziejczyk AA, Kim JK, Svensson V, Marioni JC, Teichmann SA

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An atlas of mouse CD4(+) T cell transcriptomes.

Biol Direct 2015 Apr 3;10:14

Stubbington MJ, Mahata B, Svensson V, Deonarine A, Nissen JK, Betz AG, Teichmann SA

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Structural and evolutionary versatility in protein complexes with uneven stoichiometry.

Nat Commun 2015 Mar 16;6:6394

Marsh JA, Rees HA, Ahnert SE, Teichmann SA

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Computational and analytical challenges in single-cell transcriptomics.

Nat Rev Genet 2015 Mar;16(3):133-45

Stegle O, Teichmann SA, Marioni JC

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Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells.

Nat Biotechnol 2015 Jan 19;

Buettner F, Natarajan KN, Casale FP, Proserpio V, Scialdone A, Theis FJ, Teichmann SA, Marioni JC, Stegle O

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2014

Evolution of oligomeric state through allosteric pathways that mimic ligand binding.

Science 2014 Dec 19;346(6216):1254346

Perica T, Kondo Y, Tiwari SP, McLaughlin SH, Kemplen KR, Zhang X, Steward A, Reuter N, Clarke J, Teichmann SA

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Latest publications

2017-06-27

The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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2017-05-26

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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2017-04-30

The impact of rare and low-frequency genetic variants in common disease.

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