Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Antoine Peters18 Publications.


Sperm is epigenetically programmed to regulate gene transcription in embryos.

Genome Res 2016 Mar 31;

Teperek M, Simeone A, Gaggioli V, Miyamoto K, Allen G, Erkek S, Peters A, Kwon T, Marcotte E, Zegerman P, Bradshaw C, Gurdon J, Jullien J

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Silencing of X-Linked MicroRNAs by Meiotic Sex Chromosome Inactivation.

PLoS Genet 2015 Oct;11(10):e1005461

Royo H, Seitz H, ElInati E, Peters AH, Stadler MB, Turner JM

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Disruption of histone methylation in developing sperm impairs offspring health transgenerationally.

Science 2015 Nov 6;350(6261):aab2006

Siklenka K, Erkek S, Godmann M, Lambrot R, McGraw S, Lafleur C, Cohen T, Xia J, Suderman M, Hallett M, Trasler J, Peters AH, Kimmins S

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Cbx2 Targets PRC1 to Constitutive Heterochromatin in Mouse Zygotes in a Parent-of-Origin-Dependent Manner.

Mol Cell 2015 Apr 2;58(1):157-71

Tardat M, Albert M, Kunzmann R, Liu Z, Kaustov L, Thierry R, Duan S, Brykczynska U, Arrowsmith CH, Peters AH

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Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications.

Nat Commun 2014 Dec 18;5:5868

van de Werken C, van der Heijden GW, Eleveld C, Teeuwssen M, Albert M, Baarends WM, Laven JS, Peters AH, Baart EB

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Absolute Quantification of Histone PTM Marks by MRM-based LC-MS/MS.

Anal Chem 2014 Aug 28;

Gao J, Liao R, Yu Y, Zhai H, Wang YK, Sack R, Peters A, Chen J, Wu H, Huang Z, Hu M, Qi V, Lu C, Atadja P, Oyang C, Li E, Yi W, Zhou S

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In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism.

Science 2014 Jul 10;

Radford EJ, Ito M, Shi H, Corish JA, Yamazawa K, Isganaitis E, Seisenberger S, Hore TA, Reik W, Erkek S, Peters AH, Patti ME, Ferguson-Smith AC

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Genome-wide chromatin analysis in mature mouse and human spermatozoa.

Nat Protoc 2013 Dec;8(12):2449-70

Hisano M, Erkek S, Dessus-Babus S, Ramos L, Stadler MB, Peters AH

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Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa.

Nat Struct Mol Biol 2013 Jul;20(7):868-75

Erkek S, Hisano M, Liang CY, Gill M, Murr R, Dieker J, Schübeler D, Vlag Jv, Stadler MB, Peters AH

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H3K9/HP1 and Polycomb: Two Key Epigenetic Silencing Pathways for Gene Regulation and Embryo Development.

Curr Top Dev Biol 2013;104:243-91

Nestorov P, Tardat M, Peters AH

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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