Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Jane Mellor11 Publications.


Paf1 Has Distinct Roles in Transcription Elongation and Differential Transcript Fate.

Mol Cell 2017 Feb 16;65(4):685-698.e8

Fischl H, Howe FS, Furger A, Mellor J

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Is H3K4me3 instructive for transcription activation?

Bioessays 2017 Jan;39(1):1-12

Howe FS, Fischl H, Murray SC, Mellor J

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The Chromatin Remodeler ISW1 Is a Quality Control Factor that Surveys Nuclear mRNP Biogenesis.

Cell 2016 Nov 17;167(5):1201-1214.e15

Babour A, Shen Q, Dos-Santos J, Murray S, Gay A, Challal D, Fasken M, Palancade B, Corbett A, Libri D, Mellor J, Dargemont C

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Using both strands: The fundamental nature of antisense transcription.

Bioarchitecture 2016 Jan 2;6(1):12-21

Murray SC, Mellor J

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The Interleaved Genome.

Trends Genet 2016 Jan;32(1):57-71

Mellor J, Woloszczuk R, Howe FS

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Sense and antisense transcription are associated with distinct chromatin architectures across genes.

Nucleic Acids Res 2015 Jun 29;

Murray SC, Haenni S, Howe FS, Fischl H, Chocian K, Nair A, Mellor J

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Transcription mediated insulation and interference direct gene cluster expression switches.

Elife 2014 Nov 19;3

Nguyen T, Fischl H, Howe FS, Woloszczuk R, Serra Barros A, Xu Z, Brown D, Murray SC, Haenni S, Halstead JM, O'Connor L, Shipkovenska G, Steinmeetz LM, Mellor J

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Lysine acetylation controls local protein conformation by influencing proline isomerization.

Mol Cell 2014 Sep 4;55(5):733-44

Howe FS, Boubriak I, Sale MJ, Nair A, Clynes D, Grijzenhout A, Murray SC, Woloszczuk R, Mellor J

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Analysis of C. elegans intestinal gene expression and polyadenylation by fluorescence-activated nuclei sorting and 3'-end-seq.

Nucleic Acids Res 2012 Mar 29;

Haenni S, Ji Z, Hoque M, Rust N, Sharpe H, Eberhard R, Browne C, Hengartner MO, Mellor J, Tian B, Furger A

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A pre-initiation complex at the 3'-end of genes drives antisense transcription independent of divergent sense transcription.

Nucleic Acids Res 2012 Mar;40(6):2432-44

Murray SC, Serra Barros A, Brown DA, Dudek P, Ayling J, Mellor J

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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