Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Marcel Mechali17 Publications.


Proteomic data on the nuclear interactome of human MCM9.

Data Brief 2016 Mar;6:410-5

Hutchins JR, Traver S, Coulombe P, Peiffer I, Kitzmann M, Latreille D, Méchali M

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The chromatin environment shapes DNA replication origin organization and defines origin classes.

Genome Res 2015 Nov 11;

Cayrou C, Ballester B, Peiffer I, Fenouil R, Coulombe P, Andrau JC, van Helden J, Méchali M

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MCM9 Is Required for Mammalian DNA Mismatch Repair.

Mol Cell 2015 Sep 3;59(5):831-9

Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille D, Méchali M

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DNA replication origin activation in space and time.

Nat Rev Mol Cell Biol 2015 Jun;16(6):360-74

Fragkos M, Ganier O, Coulombe P, Méchali M

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DNA Replication Origins.

Cold Spring Harb Perspect Biol 2013 Jul 9;

Leonard AC, Méchali M

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A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing.

Nat Commun 2013 Jul 1;4:2065

Coulombe P, Grégoire D, Tsanov N, Méchali M

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Genetic and epigenetic determinants of DNA replication origins, position and activation.

Curr Opin Genet Dev 2013 Mar 28;

Méchali M, Yoshida K, Coulombe P, Pasero P

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Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis.

Mol Biol Cell 2013 Jan 9;

Hua H, Namdar M, Ganier O, Gregan J, Méchali M, Kearsey SE

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Methods in DNA replication.

Methods 2012 Jun;57(2):139

Méchali M

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Genome-scale identification of active DNA replication origins.

Methods 2012 Jul 11;

Cayrou C, Grégoire D, Coulombe P, Danis E, Méchali M

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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