Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications


Information is retrieved from

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Group Leader:
Anja Groth13 Publications.

2016

H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex.

Nature 2016 Jun 22;534(7609):714-718

Saredi G, Huang H, Hammond CM, Alabert C, Bekker-Jensen S, Forne I, Reverón-Gómez N, Foster BM, Mlejnkova L, Bartke T, Cejka P, Mailand N, Imhof A, Patel DJ, Groth A

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2015

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.

J Cell Biol 2016 Jan 4;212(1):63-75

Hoffmann S, Smedegaard S, Nakamura K, Mortuza GB, Räschle M, Ibañez de Opakua A, Oka Y, Feng Y, Blanco FJ, Mann M, Montoya G, Groth A, Bekker-Jensen S, Mailand N

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BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation.

EMBO J 2015 Nov 30;

Feng Y, Vlassis A, Roques C, Lalonde ME, González-Aguilera C, Lambert JP, Lee SB, Zhao X, Alabert C, Johansen JV, Paquet E, Yang XJ, Gingras AC, Côté J, Groth A

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A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.

Nat Struct Mol Biol 2015 Aug;22(8):618-26

Huang H, Strømme CB, Saredi G, Hödl M, Strandsby A, González-Aguilera C, Chen S, Groth A, Patel DJ

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Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control.

Nat Commun 2015 Mar 30;6:6533

Gallina I, Colding C, Henriksen P, Beli P, Nakamura K, Offman J, Mathiasen DP, Silva S, Hoffmann E, Groth A, Choudhary C, Lisby M

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Two distinct modes for propagation of histone PTMs across the cell cycle.

Genes Dev 2015 Mar 15;29(6):585-90

Alabert C, Barth TK, Reverón-Gómez N, Sidoli S, Schmidt A, Jensen ON, Imhof A, Groth A

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2014

Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.

Nat Commun 2014 Mar 6;5:3394

Klimovskaia IM, Young C, Strømme CB, Menard P, Jasencakova Z, Mejlvang J, Ask K, Ploug M, Nielsen ML, Jensen ON, Groth A

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Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.

Nat Cell Biol 2014 Feb 23;

Alabert C, Bukowski-Wills JC, Lee SB, Kustatscher G, Nakamura K, de Lima Alves F, Menard P, Mejlvang J, Rappsilber J, Groth A

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New histone supply regulates replication fork speed and PCNA unloading.

J Cell Biol 2014 Jan 6;204(1):29-43

Mejlvang J, Feng Y, Alabert C, Neelsen KJ, Jasencakova Z, Zhao X, Lees M, Sandelin A, Pasero P, Lopes M, Groth A

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2012

CDK suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.

Mol Cell Biol 2012 Aug 20;

Beck H, Nähse-Kumpf V, Yoo Larsen MS, O'Hanlon KA, Patzke S, Holmberg C, Mejlvang J, Groth A, Nielsen O, Syljuåsen RG, Sørensen CS

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Latest publications

2017-06-27

The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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2017-05-26

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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2017-04-30

The impact of rare and low-frequency genetic variants in common disease.

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