Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Peter Fraser25 Publications.


GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data.

PLoS One 2017;12(4):e0174744

Mifsud B, Martincorena I, Darbo E, Sugar R, Schoenfelder S, Fraser P, Luscombe NM

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Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.

Elife 2017 Mar 23;6

Freire-Pritchett P, Schoenfelder S, Várnai C, Wingett SW, Cairns J, Collier AJ, García-Vílchez R, Furlan-Magaril M, Osborne CS, Fraser P, Rugg-Gunn PJ, Spivakov M

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HiCUP: pipeline for mapping and processing Hi-C data.

F1000Res 2015;4:1310

Wingett S, Ewels P, Furlan-Magaril M, Nagano T, Schoenfelder S, Fraser P, Andrews S

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Integrated genome-scale analysis of the transcriptional regulatory landscape in a blood stem/progenitor cell model.

Blood 2016 Jan 25;

Wilson NK, Schoenfelder S, Hannah R, Sánchez Castillo M, Schütte J, Ladopoulos V, Mitchelmore J, Goode DK, Calero-Nieto FJ, Moignard V, Wilkinson AC, Jimenez-Madrid I, Kinston S, Spivakov M, Fraser P, Göttgens B

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Ocean acidification boosts larval fish development but reduces the window of opportunity for successful settlement.

Proc Biol Sci 2015 Dec 22;282(1821)

Rossi T, Nagelkerken I, Simpson SD, Pistevos JC, Watson SA, Merillet L, Fraser P, Munday PL, Connell SD

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Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.

Nat Commun 2015 Nov 30;6:10069

Martin P, McGovern A, Orozco G, Duffus K, Yarwood A, Schoenfelder S, Cooper NJ, Barton A, Wallace C, Fraser P, Worthington J, Eyre S

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Single-cell Hi-C for genome-wide detection of chromatin interactions that occur simultaneously in a single cell.

Nat Protoc 2015 Dec;10(12):1986-2003

Nagano T, Lubling Y, Yaffe E, Wingett SW, Dean W, Tanay A, Fraser P

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Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome.

Nat Genet 2015 Aug 31;

Schoenfelder S, Sugar R, Dimond A, Javierre BM, Armstrong H, Mifsud B, Dimitrova E, Matheson L, Tavares-Cadete F, Furlan-Magaril M, Segonds-Pichon A, Jurkowski W, Wingett SW, Tabbada K, Andrews S, Herman B, LeProust E, Osborne CS, Koseki H, Fraser P, Luscombe NM, Elderkin S

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Comparison of Hi-C results using in-solution versus in-nucleus ligation.

Genome Biol 2015 Aug 26;16(1):175

Nagano T, Várnai C, Schoenfelder S, Javierre BM, Wingett SW, Fraser P

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3D genome architecture from populations to single cells.

Curr Opin Genet Dev 2015 Apr;31:36-41

Furlan-Magaril M, Várnai C, Nagano T, Fraser P

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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