Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

Information is retrieved from


Back to the index page

Group Leader:
Leonie Ringrose14 Publications.


Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.

EMBO Rep 2016 Oct 4;

Asaoka T, Almagro J, Ehrhardt C, Tsai I, Schleiffer A, Deszcz L, Junttila S, Ringrose L, Mechtler K, Kavirayani A, Gyenesei A, Hofmann K, Duchek P, Rittinger K, Ikeda F

View on PubMed


Radical Sabbaticals.

Cell 2015 Nov 5;163(4):788-9

Clevers H, Firestein S, Ringrose L, Bernards R, Darwin KH, Vance RE

View on PubMed

Reconciling randomness and precision.

Nat Rev Mol Cell Biol 2015 Nov;16(11):642

Ringrose L

View on PubMed

The quest for mammalian Polycomb response elements: are we there yet?

Chromosoma 2015 Oct 9;

Bauer M, Trupke J, Ringrose L

View on PubMed


A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element.

Nat Genet 2014 Aug 10;

Herzog VA, Lempradl A, Trupke J, Okulski H, Altmutter C, Ruge F, Boidol B, Kubicek S, Schmauss G, Aumayr K, Ruf M, Pospisilik A, Dimond A, Senergin HB, Vargas ML, Simon JA, Ringrose L

View on PubMed

What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.

Nat Rev Mol Cell Biol 2014 May;15(5):340-56

Steffen PA, Ringrose L

View on PubMed


Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin.

Nucleic Acids Res 2013 Apr 10;

Steffen PA, Fonseca JP, Gänger C, Dworschak E, Kockmann T, Beisel C, Ringrose L

View on PubMed


Epigenetics meets mathematics: Towards a quantitative understanding of chromatin biology.

Bioessays 2012 Oct;34(10):901-13

Steffen PA, Fonseca JP, Ringrose L

View on PubMed

First annual meeting of the EpiGeneSys Network of Excellence: Moving epigenetics towards systems biology.

Bioessays 2012 May 11;

Vandenberg A, Ringrose L

View on PubMed

In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells.

Genes Dev 2012 Apr 15;26(8):857-71

Fonseca JP, Steffen PA, Müller S, Lu J, Sawicka A, Seiser C, Ringrose L

View on PubMed

Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

Read more

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

Read more

The impact of rare and low-frequency genetic variants in common disease.

Read more