Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Wolf Reik67 Publications.


Uncovering the role of 5-hydroxymethylcytosine in the epigenome.

Nat Rev Genet 2011 Nov 15;13(1):7-13

Branco MR, Ficz G, Reik W

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DNA demethylases: a new epigenetic frontier in drug discovery.

Drug Discov Today 2011 Aug;16(15-16):683-90

Carey N, Marques CJ, Reik W

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Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.

Nature 2011 May 19;473(7347):398-402

Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, Marques CJ, Andrews S, Reik W

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5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming.

Nat Commun 2011;2:241

Wossidlo M, Nakamura T, Lepikhov K, Marques CJ, Zakhartchenko V, Boiani M, Arand J, Nakano T, Reik W, Walter J

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Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations.

Exp Diabetes Res 2011;2011:171376

Petry CJ, Evans ML, Wingate DL, Ong KK, Reik W, Constância M, Dunger DB

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Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth.

FASEB J 2011 May;25(5):1737-45

Angiolini E, Coan PM, Sandovici I, Iwajomo OH, Peck G, Burton GJ, Sibley CP, Reik W, Fowden AL, Constância M

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Epigenetic reprogramming in plant and animal development.

Science 2010 Oct 29;330(6004):622-7

Feng S, Jacobsen SE, Reik W

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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