Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Wolf Reik67 Publications.


A screen for hydroxymethylcytosine and formylcytosine binding proteins suggests functions in transcription and chromatin regulation.

Genome Biol 2013 Oct 24;14(10):R119

Iurlaro M, Ficz G, Oxley D, Raiber EA, Bachman M, Booth MJ, Andrews S, Balasubramanian S, Reik W

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Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine.

Nat Protoc 2013 Oct;8(10):1841-51

Booth MJ, Ost TW, Beraldi D, Bell NM, Branco MR, Reik W, Balasubramanian S

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Robust 3D DNA FISH Using Directly Labeled Probes.

J Vis Exp 2013 Aug 15;(78)

Bolland DJ, King MR, Reik W, Corcoran AE, Krueger C

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FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency.

Cell Stem Cell 2013 Jul 10;

Ficz G, Hore TA, Santos F, Lee HJ, Dean W, Arand J, Krueger F, Oxley D, Paul YL, Walter J, Cook SJ, Andrews S, Branco MR, Reik W

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Regulation of lineage specific DNA hypomethylation in mouse trophectoderm.

PLoS One 2013;8(6):e68846

Oda M, Oxley D, Dean W, Reik W

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Dnmt2-dependent methylomes lack defined DNA methylation patterns.

Proc Natl Acad Sci U S A 2013 May 21;110(21):8627-31

Raddatz G, Guzzardo PM, Olova N, Fantappié MR, Rampp M, Schaefer M, Reik W, Hannon GJ, Lyko F

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Reprogramming by cell fusion: boosted by tets.

Mol Cell 2013 Mar 28;49(6):1017-8

Ficz G, Reik W

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Conceptual links between DNA methylation reprogramming in the early embryo and primordial germ cells.

Curr Opin Cell Biol 2013 Mar 16;

Seisenberger S, Peat JR, Reik W

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NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

Nature 2013 Feb 10;

Costa Y, Ding J, Theunissen TW, Faiola F, Hore TA, Shliaha PV, Fidalgo M, Saunders A, Lawrence M, Dietmann S, Das S, Levasseur DN, Li Z, Xu M, Reik W, Silva JC, Wang J

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Direct sequencing of small genomes on the Pacific Biosciences RS without library preparation.

Biotechniques 2012 Dec;53(6):365-72

Coupland P, Chandra T, Quail M, Reik W, Swerdlow H

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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