Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Wolf Reik67 Publications.


Selective impairment of methylation maintenance is the major cause of DNA methylation reprogramming in the early embryo.

Epigenetics Chromatin 2015;8(1):1

Arand J, Wossidlo M, Lepikhov K, Peat JR, Reik W, Walter J

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Genome-wide Bisulfite Sequencing in Zygotes Identifies Demethylation Targets and Maps the Contribution of TET3 Oxidation.

Cell Rep 2014 Dec 11;

Peat JR, Dean W, Clark SJ, Krueger F, Smallwood SA, Ficz G, Kim JK, Marioni JC, Hore TA, Reik W

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Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation.

Mol Cell 2014 Nov 20;56(4):580-94

Saksouk N, Barth TK, Ziegler-Birling C, Olova N, Nowak A, Rey E, Mateos-Langerak J, Urbach S, Reik W, Torres-Padilla ME, Imhof A, Déjardin J

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Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human.

Cell 2014 Sep 11;158(6):1254-69

Takashima Y, Guo G, Loos R, Nichols J, Ficz G, Krueger F, Oxley D, Santos F, Clarke J, Mansfield W, Reik W, Bertone P, Smith A

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Epigenetics: Cellular memory erased in human embryos.

Nature 2014 Jul 31;511(7511):540-1

Reik W, Kelsey G

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Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity.

Nat Methods 2014 Aug;11(8):817-20

Smallwood SA, Lee HJ, Angermueller C, Krueger F, Saadeh H, Peat J, Andrews SR, Stegle O, Reik W, Kelsey G

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Processive DNA Demethylation via DNA Deaminase-Induced Lesion Resolution.

PLoS One 2014;9(7):e97754

Franchini DM, Chan CF, Morgan H, Incorvaia E, Rangam G, Dean W, Santos F, Reik W, Petersen-Mahrt SK

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In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism.

Science 2014 Jul 10;

Radford EJ, Ito M, Shi H, Corish JA, Yamazawa K, Isganaitis E, Seisenberger S, Hore TA, Reik W, Erkek S, Peters AH, Patti ME, Ferguson-Smith AC

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Reprogramming the Methylome: Erasing Memory and Creating Diversity.

Cell Stem Cell 2014 Jun 5;14(6):710-719

Lee HJ, Hore TA, Reik W

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Etoposide Induces Nuclear Re-Localisation of AID.

PLoS One 2013 Dec 4;8(12):e82110

Lambert LJ, Walker S, Feltham J, Lee HJ, Reik W, Houseley J

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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