Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Wolf Reik67 Publications.


Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

Cell Rep 2017 May 23;19(8):1503-1511

Kirschner K, Chandra T, Kiselev V, Flores-Santa Cruz D, Macaulay IC, Park HJ, Li J, Kent DG, Kumar R, Pask DC, Hamilton TL, Hemberg M, Reik W, Green AR

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Erratum to: DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning.

Genome Biol 2017 May 12;18(1):90

Angermueller C, Lee HJ, Reik W, Stegle O

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Multi-tissue DNA methylation age predictor in mouse.

Genome Biol 2017 Apr 11;18(1):68

Stubbs TM, Bonder MJ, Stark AK, Krueger F, BI Ageing Clock Team., von Meyenn F, Stegle O, Reik W

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Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.

Genome Biol 2017 Mar 28;18(1):56

Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q, Wakelam MJ, Beyer A, Reik W, Partridge L

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SC3: consensus clustering of single-cell RNA-seq data.

Nat Methods 2017 May;14(5):483-486

Kiselev VY, Kirschner K, Schaub MT, Andrews T, Yiu A, Chandra T, Natarajan KN, Reik W, Barahona M, Green AR, Hemberg M

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DNA methylation homeostasis in human and mouse development.

Curr Opin Genet Dev 2017 Mar 2;43:101-109

Iurlaro M, von Meyenn F, Reik W

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The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice.

Genes (Basel) 2017 Feb 17;8(2)

Langie SA, Cameron KM, Ficz G, Oxley D, Tomaszewski B, Gorniak JP, Maas LM, Godschalk RW, van Schooten FJ, Reik W, von Zglinicki T, Mathers JC

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Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq).

Nat Protoc 2017 Mar;12(3):534-547

Clark SJ, Smallwood SA, Lee HJ, Krueger F, Reik W, Kelsey G

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Tracking the embryonic stem cell transition from ground state pluripotency.

Development 2017 Apr 1;144(7):1221-1234

Kalkan T, Olova N, Roode M, Mulas C, Lee HJ, Nett I, Marks H, Walker R, Stunnenberg HG, Lilley KS, Nichols J, Reik W, Bertone P, Smith A

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Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.

Cell Rep 2017 Jan 31;18(5):1079-1089

Milagre I, Stubbs TM, King MR, Spindel J, Santos F, Krueger F, Bachman M, Segonds-Pichon A, Balasubramanian S, Andrews SR, Dean W, Reik W

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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