Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Christian Muchardt14 Publications.


Transcriptional activity of endogenous retroviruses in multiple sclerosis: a sign of deficient chromatin-mediated silencing.

Epigenomics 2015 Dec;7(8):1235-7

Muchardt C

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Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors.

Oncotarget 2015 Jul 30;6(21):18518-33

Ayadi M, Bouygues A, Ouaret D, Ferrand N, Chouaib S, Thiery JP, Muchardt C, Sabbah M, Larsen AK

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Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions.

Nucleic Acids Res 2015 Jan 20;

Mauger O, Klinck R, Chabot B, Muchardt C, Allemand E, Batsché E

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The translation elongation factor eEF1A1 couples transcription to translation during heat shock response.

Elife 2014 Sep 16;3

Vera M, Pani B, Griffiths LA, Muchardt C, Abbott CM, Singer RH, Nudler E

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Shigella flexneri targets the HP1γ subcode through the phosphothreonine lyase OspF.

EMBO J 2014 Sep 12;

Harouz H, Rachez C, Meijer BM, Marteyn B, Donnadieu F, Cammas F, Muchardt C, Sansonetti P, Arbibe L

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DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression.

EMBO Rep 2014 May 12;

Jang SM, Azebi S, Soubigou G, Muchardt C

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Systematic Identification of Proteins Binding to Chromatin-Embedded Ubiquitylated H2B Reveals Recruitment of SWI/SNF to Regulate Transcription.

Cell Rep 2013 Aug 15;4(3):601-8

Shema-Yaacoby E, Nikolov M, Haj-Yahya M, Siman P, Allemand E, Yamaguchi Y, Muchardt C, Urlaub H, Brik A, Oren M, Fischle W

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10-million-years AGO: Argonaute on chromatin in yeast and human, a conserved mode of action?

Transcription 2013 Apr 12;4(3)

Harel-Bellan A, Zazoua MA, Rachez C, Muchardt C, Batshé E

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S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration.

Proc Natl Acad Sci U S A 2013 Feb 19;110(8):3113-8

Nott A, Nitarska J, Veenvliet JV, Schacke S, Derijck AA, Sirko P, Muchardt C, Pasterkamp RJ, Smidt MP, Riccio A

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Citrullination of Histone H3 Interferes with HP1-Mediated Transcriptional Repression.

PLoS Genet 2012 Sep;8(9):e1002934

Sharma P, Azebi S, England P, Christensen T, Møller-Larsen A, Petersen T, Batsché E, Muchardt C

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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