Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications


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Group Leader:
Gavin Kelsey21 Publications.

2017

Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq).

Nat Protoc 2017 Mar;12(3):534-547

Clark SJ, Smallwood SA, Lee HJ, Krueger F, Reik W, Kelsey G

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2016

Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity.

Genome Biol 2016 Apr 18;17(1):72

Clark SJ, Lee HJ, Smallwood SA, Kelsey G, Reik W

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Pervasive polymorphic imprinted methylation in the human placenta.

Genome Res 2016 Jan 14;

Hanna CW, Peñaherrera MS, Saadeh H, Andrews S, McFadden DE, Kelsey G, Robinson WP

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Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity.

Nat Methods 2016 Jan 11;

Angermueller C, Clark SJ, Lee HJ, Macaulay IC, Teng MJ, Hu TX, Krueger F, Smallwood SA, Ponting CP, Voet T, Kelsey G, Stegle O, Reik W

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2015

Erratum to: Deep sequencing and de novo assembly of the mouse occyte transcriptome define the contribution of transcription to the DNA methylation landscape.

Genome Biol 2015 Dec 3;16:271

Veselovska L, Smallwood SA, Saadeh H, Stewart KR, Krueger F, Maupetit-Méhouas S, Arnaud P, Tomizawa S, Andrews S, Kelsey G

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Dynamic changes in histone modifications precede de novo DNA methylation in oocytes.

Genes Dev 2015 Dec 1;29(23):2449-62

Stewart KR, Veselovska L, Kim J, Huang J, Saadeh H, Tomizawa S, Smallwood SA, Chen T, Kelsey G

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Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis.

Mol Cell 2015 Nov 19;60(4):611-25

Nashun B, Hill PW, Smallwood SA, Dharmalingam G, Amouroux R, Clark SJ, Sharma V, Ndjetehe E, Pelczar P, Festenstein RJ, Kelsey G, Hajkova P

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Keeping methylation at bay.

Nat Genet 2015 May;47(5):427-8

Kelsey G

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2014

Epigenetics: Cellular memory erased in human embryos.

Nature 2014 Jul 31;511(7511):540-1

Reik W, Kelsey G

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Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity.

Nat Methods 2014 Aug;11(8):817-20

Smallwood SA, Lee HJ, Angermueller C, Krueger F, Saadeh H, Peat J, Andrews SR, Stegle O, Reik W, Kelsey G

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Latest publications

2017-06-27

The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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2017-05-26

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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2017-04-30

The impact of rare and low-frequency genetic variants in common disease.

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