Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Fabrizio D'Adda di Fagagna19 Publications.


DICER, DROSHA and DNA damage-response RNAs are necessary for the secondary recruitment of DNA damage response factors.

J Cell Sci 2016 Feb 16;

Francia S, Cabrini M, Matti V, Oldani A, d'Adda di Fagagna F

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Human nuclear ARGONAUTE 2 interacts in vivo only with small RNAs and not with DNA.

Cell Cycle 2015 Jul 3;14(13):2001-2

Gioia U, d'Adda di Fagagna F

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Notch is a direct negative regulator of the DNA-damage response.

Nat Struct Mol Biol 2015 May;22(5):417-24

Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F

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Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.

EMBO J 2015 Mar 27;

Meena JK, Cerutti A, Beichler C, Morita Y, Bruhn C, Kumar M, Kraus JM, Speicher MR, Wang ZQ, Kestler HA, d'Adda di Fagagna F, Günes C, Rudolph KL

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RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.

EMBO Rep 2014 Dec 19;

Manfrini N, Trovesi C, Wery M, Martina M, Cesena D, Descrimes M, Morillon A, d'Adda di Fagagna F, Longhese MP

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Stable Cellular Senescence Is Associated with Persistent DDR Activation.

PLoS One 2014;9(10):e110969

Fumagalli M, Rossiello F, Mondello C, d'Adda di Fagagna F

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Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

Curr Opin Genet Dev 2014 Aug 4;26C:89-95

Rossiello F, Herbig U, Longhese MP, Fumagalli M, d'Adda di Fagagna F

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Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.

Nat Commun 2014 Apr 14;5:3649

Piunti A, Rossi A, Cerutti A, Albert M, Jammula S, Scelfo A, Cedrone L, Fragola G, Olsson L, Koseki H, Testa G, Casola S, Helin K, d'Adda di Fagagna F, Pasini D

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DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT.

Stem Cell Reports 2013 Jul 25;1(2):123-38

Schneider L, Pellegatta S, Favaro R, Pisati F, Roncaglia P, Testa G, Nicolis SK, Finocchiaro G, d'Adda di Fagagna F

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Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer.

Nat Rev Cancer 2012 Oct;12(10):709-20

Sulli G, Di Micco R, d'Adda di Fagagna F

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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