Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Stephen Cusack51 Publications.


Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.

PLoS One 2017;12(5):e0177161

Pellegrini E, Signor L, Singh S, Boeri Erba E, Cusack S

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Structural insights into reptarenavirus cap-snatching machinery.

PLoS Pathog 2017 May 15;13(5):e1006400

Rosenthal M, Gogrefe N, Vogel D, Reguera J, Rauschenberger B, Cusack S, Günther S, Reindl S

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Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.

EMBO Mol Med 2017 Mar;9(3):385-394

Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA

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An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase.

Nucleic Acids Res 2017 Apr 7;45(6):3353-3368

Reich S, Guilligay D, Cusack S

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Structural insights into RNA synthesis by the influenza virus transcription-replication machine.

Virus Res 2017 Jan 20;

Pflug A, Lukarska M, Resa-Infante P, Reich S, Cusack S

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Structural basis of an essential interaction between influenza polymerase and Pol II CTD.

Nature 2017 Jan 5;541(7635):117-121

Lukarska M, Fournier G, Pflug A, Resa-Infante P, Reich S, Naffakh N, Cusack S

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Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

Nat Commun 2016 Oct 7;7:12928

Chopra S, Palencia A, Virus C, Schulwitz S, Temple BR, Cusack S, Reader J

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Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase.

Antimicrob Agents Chemother 2016 Aug 8;

Palencia A, Li X, Bu W, Choi W, Ding CZ, Easom EE, Feng L, Hernandez V, Houston P, Liu L, Meewan M, Mohan M, Rock FL, Sexton H, Zhang S, Zhou Y, Wan B, Wang Y, Franzblau SG, Woolhiser L, Gruppo V, Lenaerts AJ, O'Malley T, Parish T, Cooper CB, Waters MG, Ma Z, Ioerger TR, Sacchettini JC, Rullas J, Angulo-Barturen I, Pérez-Herrán E, Mendoza A, Barros D, Cusack S, Plattner JJ, Alley MR

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Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase.

Antimicrob Agents Chemother 2016 Jul 18;

Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S

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Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.

PLoS Pathog 2016 Jun;12(6):e1005636

Reguera J, Gerlach P, Rosenthal M, Gaudon S, Coscia F, Günther S, Cusack S

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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The impact of rare and low-frequency genetic variants in common disease.

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