Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Ann Ehrenhofer-Murray10 Publications.


Widespread colocalization of the Drosophila histone acetyltransferase homolog MYST5 with DREF and insulator proteins at active genes.

Chromosoma 2016 Feb 19;

Heseding C, Saumweber H, Rathke C, Ehrenhofer-Murray AE

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Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine.

Nucleic Acids Res 2015 Sep 30;

Müller M, Hartmann M, Schuster I, Bender S, Thüring KL, Helm M, Katze JR, Nellen W, Lyko F, Ehrenhofer-Murray AE

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A link between Sas2-mediated H4 K16 acetylation, chromatin assembly in S-phase by CAF-I and Asf1, and nucleosome assembly by Spt6 during transcription.

FEMS Yeast Res 2015 Nov;15(7)

Reiter C, Heise F, Chung HR, Ehrenhofer-Murray AE

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A Method for High-Throughput Analysis of Chronological Aging in Schizosaccharomyces pombe.

Methods Mol Biol 2015;1263:93-101

Stephan J, Ehrenhofer-Murray AE

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A novel SIRT2 inhibitor with p53-dependent pro-apoptotic activity in non-small-cell lung cancer.

J Biol Chem 2013 Dec 30;

Hoffmann G, Breitenbuecher F, Schuler M, Ehrenhofer-Murray AE

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Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission and cellular GMP levels in lifespan extension.

Aging Cell 2013 Mar 23;

Stephan J, Franke J, Ehrenhofer-Murray AE

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Coal mining meets chromatin research: Digging for mechanisms in epigenetic control of gene expression: Report from the 43(rd) Annual Meeting of the German Genetics Society on "Chromatin and Epigenetics" in Essen, Germany.

Bioessays 2012 Dec 4;

Ehrenhofer-Murray A, Meyer H, Nellen W

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Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregation.

Proc Natl Acad Sci U S A 2012 Jun 5;109(23):9029-34

Samel A, Cuomo A, Bonaldi T, Ehrenhofer-Murray AE

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Genome-wide H4 K16 acetylation by SAS-I is deposited independently of transcription and histone exchange.

Nucleic Acids Res 2012 Jan;40(1):65-74

Heise F, Chung HR, Weber JM, Xu Z, Klein-Hitpass L, Steinmetz LM, Vingron M, Ehrenhofer-Murray AE

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Structural basis for the role of the Sir3 AAA+ domain in silencing: interaction with Sir4 and unmethylated histone H3K79.

Genes Dev 2011 Sep 1;25(17):1835-46

Ehrentraut S, Hassler M, Oppikofer M, Kueng S, Weber JM, Mueller JW, Gasser SM, Ladurner AG, Ehrenhofer-Murray AE

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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