Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Stephan Beck95 Publications.


Validation of the MethylationEPIC BeadChip for fresh-frozen and formalin-fixed paraffin-embedded tumours.

Clin Epigenetics 2017;9:33

Kling T, Wenger A, Beck S, Carén H

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Epigenome-wide association studies for cancer biomarker discovery in circulating cell-free DNA: technical advances and challenges.

Curr Opin Genet Dev 2017 Feb 16;42:48-55

Tanić M, Beck S

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Epigenetic variation taking center stage in immunological research.

Epigenomics 2017 Apr;9(4):375-378

Ecker S, Beck S

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Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome.

Genome Biol 2017 Mar 10;18(1):50

Cheung WA, Shao X, Morin A, Siroux V, Kwan T, Ge B, Aïssi D, Chen L, Vasquez L, Allum F, Guénard F, Bouzigon E, Simon MM, Boulier E, Redensek A, Watt S, Datta A, Clarke L, Flicek P, Mead D, Paul DS, Beck S, Bourque G, Lathrop M, Tchernof A, Vohl MC, Demenais F, Pin I, Downes K, Stunnenberg HG, Soranzo N, Pastinen T, Grundberg E

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Correcting for cell-type heterogeneity in epigenome-wide association studies: revisiting previous analyses.

Nat Methods 2017 Feb 28;14(3):216-217

Zheng SC, Beck S, Jaffe AE, Koestler DC, Hansen KD, Houseman AE, Irizarry RA, Teschendorff AE

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A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies.

BMC Bioinformatics 2017 Feb 13;18(1):105

Teschendorff AE, Breeze CE, Zheng SC, Beck S

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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Nat Commun 2017 Feb 10;8:14262

Schütte M, Risch T, Abdavi-Azar N, Boehnke K, Schumacher D, Keil M, Yildiriman R, Jandrasits C, Borodina T, Amstislavskiy V, Worth CL, Schweiger C, Liebs S, Lange M, Warnatz HJ, Butcher LM, Barrett JE, Sultan M, Wierling C, Golob-Schwarzl N, Lax S, Uranitsch S, Becker M, Welte Y, Regan JL, Silvestrov M, Kehler I, Fusi A, Kessler T, Herwig R, Landegren U, Wienke D, Nilsson M, Velasco JA, Garin-Chesa P, Reinhard C, Beck S, Schäfer R, Regenbrecht CR, Henderson D, Lange B, Haybaeck J, Keilholz U, Hoffmann J, Lehrach H, Yaspo ML

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UroMark-a urinary biomarker assay for the detection of bladder cancer.

Clin Epigenetics 2017;9:8

Feber A, Dhami P, Dong L, de Winter P, Tan WS, Martínez-Fernández M, Paul DS, Hynes-Allen A, Rezaee S, Gurung P, Rodney S, Mehmood A, Villacampa F, de la Rosa F, Jameson C, Cheng KK, Zeegers MP, Bryan RT, James ND, Paramio JM, Freeman A, Beck S, Kelly JD

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Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.

Genome Biol 2017 Jan 26;18(1):18

Ecker S, Chen L, Pancaldi V, Bagger FO, Fernández JM, Carrillo de Santa Pau E, Juan D, Mann AL, Watt S, Casale FP, Sidiropoulos N, Rapin N, Merkel A, BLUEPRINT Consortium., Stunnenberg HG, Stegle O, Frontini M, Downes K, Pastinen T, Kuijpers TW, Rico D, Valencia A, Beck S, Soranzo N, Paul DS

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Dynamic Consent: a potential solution to some of the challenges of modern biomedical research.

BMC Med Ethics 2017 Jan 25;18(1):4

Budin-Ljøsne I, Teare HJ, Kaye J, Beck S, Bentzen HB, Caenazzo L, Collett C, D'Abramo F, Felzmann H, Finlay T, Javaid MK, Jones E, Katić V, Simpson A, Mascalzoni D

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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