Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Asifa Akhtar25 Publications.


DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome.

Nature 2017 Apr 6;544(7648):115-119

Aktaş T, Avşar Ilık İ, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G, Manke T, Backofen R, Akhtar A

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MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.

Cell 2016 Oct 20;167(3):722-738.e23

Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A

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Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.

Nat Struct Mol Biol 2016 May 16;

Chlamydas S, Holz H, Samata M, Chelmicki T, Georgiev P, Pelechano V, Dündar F, Dasmeh P, Mittler G, Cadete FT, Ramírez F, Conrad T, Wei W, Raja S, Manke T, Luscombe NM, Steinmetz LM, Akhtar A

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Rapid evolutionary turnover underlies conserved lncRNA-genome interactions.

Genes Dev 2016 Jan 15;30(2):191-207

Quinn JJ, Zhang QC, Georgiev P, Ilik IA, Akhtar A, Chang HY

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High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila.

Mol Cell 2015 Oct 1;60(1):146-62

Ramírez F, Lingg T, Toscano S, Lam KC, Georgiev P, Chung HR, Lajoie BR, de Wit E, Zhan Y, de Laat W, Dekker J, Manke T, Akhtar A

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MOF maintains transcriptional programs regulating cellular stress response.

Oncogene 2016 May;35(21):2698-710

Sheikh BN, Bechtel-Walz W, Lucci J, Karpiuk O, Hild I, Hartleben B, Vornweg J, Helmstädter M, Sahyoun AH, Bhardwaj V, Stehle T, Diehl S, Kretz O, Voss AK, Thomas T, Manke T, Huber TB, Akhtar A

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An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis.

Nat Commun 2015 Aug 5;6:7889

Meunier S, Shvedunova M, Van Nguyen N, Avila L, Vernos I, Akhtar A

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The MSL complex: juggling RNA-protein interactions for dosage compensation and beyond.

Curr Opin Genet Dev 2015 Apr;31:1-11

Keller CI, Akhtar A

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Considerations when investigating lncRNA function in vivo.

Elife 2014 Aug 14;3:e03058

Bassett AR, Akhtar A, Barlow DP, Bird AP, Brockdorff N, Duboule D, Ephrussi A, Ferguson-Smith AC, Gingeras TR, Haerty W, Higgs DR, Miska EA, Ponting CP

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Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification.

Nat Biotechnol 2014 Jul 6;

Quinn JJ, Ilik IA, Qu K, Georgiev P, Chu C, Akhtar A, Chang HY

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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