Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Ben Lehner9 Publications.


The complete local genotype-phenotype landscape for the alternative splicing of a human exon.

Nat Commun 2016 May 10;7:11558

Julien P, Miñana B, Baeza-Centurion P, Valcárcel J, Lehner B

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Mechanisms, timescales and principles of trans-generational epigenetic inheritance in animals.

Curr Opin Genet Dev 2016 Apr 30;36:41-49

Klosin A, Lehner B

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Reconstructing and analysing cellular states, space and time from gene expression profiles of many cells and single cells.

Mol Biosyst 2015 Sep 15;11(10):2690-8

Francesconi M, Lehner B

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Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage.

Nat Commun 2015 Aug 13;6:7972

van Dijk D, Dhar R, Missarova AM, Espinar L, Blevins WR, Lehner B, Carey LB

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Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types.

Mol Syst Biol 2015 Jul 30;11(7):824

Park S, Lehner B

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Systems biology: Network evolution hinges on history.

Nature 2015 Jul 16;523(7560):297-8

New AM, Lehner B

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Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses.

PLoS Comput Biol 2015 May;11(5):e1004256

Toufighi K, Yang JS, Luis NM, Aznar Benitah S, Lehner B, Serrano L, Kiel C

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Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis.

Dev Biol 2014 Oct 28;

Krüger AV, Jelier R, Dzyubachyk O, Zimmerman T, Meijering E, Lehner B

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Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.

Cell Rep 2014 Sep 25;8(6):1609-16

Barberán-Soler S, Fontrodona L, Ribó A, Lamm AT, Iannone C, Cerón J, Lehner B, Valcárcel J

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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