Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Manuel Irimia4 Publications.


Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals.

Elife 2015 Oct 14;4

de Mendoza A, Suga H, Permanyer J, Irimia M, Ruiz-Trillo I

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The alternative splicing factor Nova2 regulates vascular development and lumen formation.

Nat Commun 2015 Oct 8;6:8479

Giampietro C, Deflorian G, Gallo S, Di Matteo A, Pradella D, Bonomi S, Belloni E, Nyqvist D, Quaranta V, Confalonieri S, Bertalot G, Orsenigo F, Pisati F, Ferrero E, Biamonti G, Fredrickx E, Taveggia C, Wyatt CD, Irimia M, Di Fiore PP, Blencowe BJ, Dejana E, Ghigna C

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A highly conserved program of neuronal microexons is misregulated in autistic brains.

Cell 2014 Dec 18;159(7):1511-23

Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T, Babor M, Quesnel-Vallières M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, Geschwind DH, Blencowe BJ

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Stability depends on positive autoregulation in Boolean gene regulatory networks.

PLoS Comput Biol 2014 Nov;10(11):e1003916

Pinho R, Garcia V, Irimia M, Feldman MW

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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