Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Gaelle Legube9 Publications.


The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.

Mol Cell 2016 May 5;62(3):409-21

Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J

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Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks.

Cell Rep 2015 Nov 24;13(8):1598-609

Caron P, Choudjaye J, Clouaire T, Bugler B, Daburon V, Aguirrebengoa M, Mangeat T, Iacovoni JS, Álvarez-Quilón A, Cortés-Ledesma F, Legube G

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DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.

Nucleic Acids Res 2015 Nov 17;

Cristini A, Park JH, Capranico G, Legube G, Favre G, Sordet O

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Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

Genes Dev 2015 Jan 15;29(2):197-211

Gong F, Chiu LY, Cox B, Aymard F, Clouaire T, Leung JW, Cammarata M, Perez M, Agarwal P, Brodbelt JS, Legube G, Miller KM

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SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability.

Cell Rep 2014 Jun 11;

Pfister SX, Ahrabi S, Zalmas LP, Sarkar S, Aymard F, Bachrati CZ, Helleday T, Legube G, La Thangue NB, Porter AC, Humphrey TC

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Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks.

Nat Struct Mol Biol 2014 Apr;21(4):366-74

Aymard F, Bugler B, Schmidt CK, Guillou E, Caron P, Briois S, Iacovoni JS, Daburon V, Miller KM, Jackson SP, Legube G

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Quantifying DNA double-strand breaks induced by site-specific endonucleases in living cells by ligation-mediated purification.

Nat Protoc 2014 Mar;9(3):517-28

Chailleux C, Aymard F, Caron P, Daburon V, Courilleau C, Canitrot Y, Legube G, Trouche D

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Quantitation of DNA double-strand break resection intermediates in human cells.

Nucleic Acids Res 2013 Dec 19;

Zhou Y, Caron P, Legube G, Paull TT

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Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break.

Nat Struct Mol Biol 2014 Jan;21(1):103-9

Lee CS, Lee K, Legube G, Haber JE

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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