Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Vardhman Rakyan14 Publications.


eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data.

Cell Rep 2016 Nov 15;17(8):2137-2150

Breeze CE, Paul DS, van Dongen J, Butcher LM, Ambrose JC, Barrett JE, Lowe R, Rakyan VK, Iotchkova V, Frontini M, Downes K, Ouwehand WH, Laperle J, Jacques PÉ, Bourque G, Bergmann AK, Siebert R, Vellenga E, Saeed S, Matarese F, Martens JH, Stunnenberg HG, Teschendorff AE, Herrero J, Birney E, Dunham I, Beck S

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Correlation of an epigenetic mitotic clock with cancer risk.

Genome Biol 2016 Oct 3;17(1):205

Yang Z, Wong A, Kuh D, Paul DS, Rakyan VK, Leslie RD, Zheng SC, Widschwendter M, Beck S, Teschendorff AE

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A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation.

Genome Med 2015 Dec 15;7(1):128

Paul DS, Jones A, Sellar RS, Mayor NP, Feber A, Webster AP, Afonso N, Sergeant R, Szydlo RM, Apperley JF, Widschwendter M, Mackinnon S, Marsh SG, Madrigal JA, Rakyan VK, Peggs KS, Beck S

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The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans.

Genome Biol 2015 Sep 17;16(1):194

Lowe R, Overhoff MG, Ramagopalan SV, Garbe JC, Koh J, Stampfer MR, Beach DH, Rakyan VK, Bishop CL

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Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development.

BMC Genomics 2015 Apr 14;16(1):295

Lowe R, Gemma C, Rakyan VK, Holland ML

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Maternal Gestational Diabetes Is Associated With Genome-wide DNA Methylation Variation In Placenta And Cord Blood Of Exposed Offspring.

Hum Mol Genet 2015 Jan 29;

Finer S, Mathews C, Lowe R, Smart M, Hillman S, Foo L, Sinha A, Williams D, Rakyan VK, Hitman GA

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The human blood DNA methylome displays a highly distinctive profile compared with other somatic tissues.

Epigenetics 2015 Jan 29;:0

Lowe R, Slodkowicz G, Goldman N, Rakyan VK

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Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates.

Epigenetics 2014 Dec 10;:0

Hillman SL, Finer S, Smart MC, Mathews C, Lowe R, Rakyan V, Hitman GA, Williams DJ

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Correcting for cell-type composition bias in epigenome-wide association studies.

Genome Med 2014;6(3):23

Lowe R, Rakyan VK

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Marmal-aid - a database for Infinium HumanMethylation450.

BMC Bioinformatics 2013 Dec 12;14(1):359

Lowe R, Rakyan VK

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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