Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Bas Heijmans34 Publications.


Epigenomic analysis of Sézary syndrome defines patterns of aberrant DNA methylation and identifies diagnostic markers.

J Invest Dermatol 2016 Apr 22;

van Doorn R, Slieker RC, Boonk SE, Zoutman WH, Goeman JJ, Bagot M, Michel L, Tensen CP, Willemze R, Heijmans BT, Vermeer MH

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Genetic and environmental influences interact with age and sex in shaping the human methylome.

Nat Commun 2016 Apr 7;7:11115

van Dongen J, Nivard MG, Willemsen G, Hottenga JJ, Helmer Q, Dolan CV, Ehli EA, Davies GE, van Iterson M, Breeze CE, Beck S, BIOS Consortium, Suchiman HE, Jansen R, van Meurs JB, Heijmans BT, Slagboom PE, Boomsma DI

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Developmental programming: State-of-the-science and future directions: Summary from a Pennington Biomedical symposium.

Obesity (Silver Spring) 2016 Apr 1;

Sutton EF, Gilmore LA, Dunger DB, Heijmans BT, Hivert MF, Ling C, Martinez JA, Ozanne SE, Simmons RA, Szyf M, Waterland RA, Redman LM, Ravussin E

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The multifaceted interplay between lipids and epigenetics.

Curr Opin Lipidol 2016 Mar 30;

Dekkers KF, Slagboom PE, Jukema JW, Heijmans BT

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Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells.

Osteoarthritis Cartilage 2016 Mar 17;

Bomer N, den Hollander W, Suchiman H, Houtman E, Slieker RC, Heijmans BT, Slagboom PE, Nelissen RG, Ramos YF, Meulenbelt I

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Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies.

Eur J Clin Pharmacol 2015 Dec 19;

Trompet S, Postmus I, Slagboom PE, Heijmans BT, Smit RA, Maier AB, Buckley BM, Sattar N, Stott DJ, Ford I, Westendorp RG, de Craen AJ, Jukema JW

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Epigenome-Wide Association Study of Aggressive Behavior.

Twin Res Hum Genet 2015 Oct 28;:1-13

van Dongen J, Nivard MG, Baselmans BM, Zilhão NR, Ligthart L, BIOS Consortium, Heijmans BT, Bartels M, Boomsma DI

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DNA Methylation Landscapes of Human Fetal Development.

PLoS Genet 2015 Oct;11(10):e1005583

Slieker RC, Roost MS, van Iperen L, Suchiman HE, Tobi EW, Carlotti F, de Koning EJ, Slagboom PE, Heijmans BT, Chuva de Sousa Lopes SM

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Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER.

Front Genet 2015;6:287

Suchiman HE, Slieker RC, Kremer D, Slagboom PE, Heijmans BT, Tobi EW

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Prenatal parental tobacco smoking, gene specific DNA methylation, and newborns size: the Generation R study.

Clin Epigenetics 2015;7(1):83

Bouwland-Both MI, van Mil NH, Tolhoek CP, Stolk L, Eilers PH, Verbiest MM, Heijmans BT, Uitterlinden AG, Hofman A, van Ijzendoorn MH, Duijts L, de Jongste JC, Tiemeier H, Steegers EA, Jaddoe VW, Steegers-Theunissen RP

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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