Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Miguel Constancia8 Publications.


Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.

Diabetologia 2015 Dec 23;

Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M

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Intergenerational epigenetic inheritance in models of developmental programming of adult disease.

Semin Cell Dev Biol 2015 Jun 30;

Fernandez-Twinn DS, Constância M, Ozanne SE

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Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.

Cardiovasc Res 2015 Jan 5;

Shen H, Cavallero S, Estrada KD, Sandovici I, Kumar SR, Makita T, Lien C, Constancia M, Sucov HM

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Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk.

FASEB J 2014 Aug 21;

Quilter CR, Cooper WN, Cliffe KM, Skinner BM, Prentice PM, Nelson L, Bauer J, Ong KK, Constância M, Lowe WL, Affara NA, Dunger DB

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Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver.

FASEB J 2014 Jan 30;

Carr SK, Chen JH, Cooper WN, Constância M, Yeo GS, Ozanne SE

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Placental programming of anxiety in adulthood revealed by Igf2-null models.

Nat Commun 2013 Aug 6;4:2311

Mikaelsson MA, Constância M, Dent CL, Wilkinson LS, Humby T

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An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory.

FASEB J 2013 Jul 15;

Sferruzzi-Perri AN, Vaughan OR, Haro M, Cooper WN, Musial B, Charalambous M, Pestana D, Ayyar S, Ferguson-Smith AC, Burton GJ, Constancia M, Fowden AL

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Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes.

Cell Mol Life Sci 2013 May;70(9):1575-95

Sandovici I, Hammerle CM, Ozanne SE, Constância M

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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