Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Petra Hajkova15 Publications.


Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.

Mol Carcinog 2017 Feb 20;

Benešová M, Trejbalová K, Kučerová D, Vernerová Z, Hron T, Szabó A, Amouroux R, Klézl P, Hajkova P, Hejnar J

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De novo DNA methylation drives 5hmC accumulation in mouse zygotes.

Nat Cell Biol 2016 Feb;18(2):225-33

Amouroux R, Nashun B, Shirane K, Nakagawa S, Hill PW, D'Souza Z, Nakayama M, Matsuda M, Turp A, Ndjetehe E, Encheva V, Kudo NR, Koseki H, Sasaki H, Hajkova P

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Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis.

Mol Cell 2015 Nov 19;60(4):611-25

Nashun B, Hill PW, Smallwood SA, Dharmalingam G, Amouroux R, Clark SJ, Sharma V, Ndjetehe E, Pelczar P, Festenstein RJ, Kelsey G, Hajkova P

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Reprogramming of cell fate: epigenetic memory and the erasure of memories past.

EMBO J 2015 Mar 27;

Nashun B, Hill PW, Hajkova P

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Hydroxymethylated cytosines are associated with elevated C to g transversion rates.

PLoS Genet 2014 Sep;10(9):e1004585

Supek F, Lehner B, Hajkova P, Warnecke T

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DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: An emerging complex story.

Genomics 2014 Aug 27;

Hill PW, Amouroux R, Hajkova P

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Complementary roles of mouse lipocalins in chemical communication and immunity.

Biochem Soc Trans 2014 Aug 1;42(4):893-8

Stopková R, Dudková B, Hájková P, Stopka P

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The impact of culture on epigenetic properties of pluripotent stem cells and pre-implantation embryos.

Biochem Soc Trans 2013 Jun;41(3):711-9

McEwen KR, Leitch HG, Amouroux R, Hajkova P

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Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion.

Mol Cell 2013 Mar 28;49(6):1023-33

Piccolo FM, Bagci H, Brown KE, Landeira D, Soza-Ried J, Feytout A, Mooijman D, Hajkova P, Leitch HG, Tada T, Kriaucionis S, Dawlaty MM, Jaenisch R, Merkenschlager M, Fisher AG

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Naive pluripotency is associated with global DNA hypomethylation.

Nat Struct Mol Biol 2013 Mar;20(3):311-6

Leitch HG, McEwen KR, Turp A, Encheva V, Carroll T, Grabole N, Mansfield W, Nashun B, Knezovich JG, Smith A, Surani MA, Hajkova P

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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