Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Nils Blüthgen21 Publications.


Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants.

Stem Cells Transl Med 2016 Apr;5(4):476-487

Hoelting L, Klima S, Karreman C, Grinberg M, Meisig J, Henry M, Rotshteyn T, Rahnenführer J, Blüthgen N, Sachinidis A, Waldmann T, Leist M

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Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis.

Oncotarget 2016 Jan 20;

Fritsche-Guenther R, Witzel F, Kempa S, Brummer T, Sers C, Blüthgen N

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Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.

Oncotarget 2015 Dec 29;

Rohwer N, Bindel F, Grimm C, Lin SJ, Wappler J, Klinger B, Blüthgen N, Du Bois I, Schmeck B, Lehrach H, de Graauw M, Goncalves E, Saez-Rodriguez J, Tan P, Grabsch HI, Prigione A, Kempa S, Cramer T

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A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.

Arch Toxicol 2015 Sep;89(9):1599-618

Rempel E, Hoelting L, Waldmann T, Balmer NV, Schildknecht S, Grinberg M, Das Gaspar JA, Shinde V, Stöber R, Marchan R, van Thriel C, Liebing J, Meisig J, Blüthgen N, Sachinidis A, Rahnenführer J, Hengstler JG, Leist M

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RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.

Nat Commun 2015 Jul 14;6:7367

Murakawa Y, Hinz M, Mothes J, Schuetz A, Uhl M, Wyler E, Yasuda T, Mastrobuoni G, Friedel CC, Dölken L, Kempa S, Schmidt-Supprian M, Blüthgen N, Backofen R, Heinemann U, Wolf J, Scheidereit C, Landthaler M

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Bacterial computing with engineered populations.

Philos Trans A Math Phys Eng Sci 2015 Jul 28;373(2046)

Amos M, Axmann IM, Blüthgen N, de la Cruz F, Jaramillo A, Rodriguez-Paton A, Simmel F

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Signal integration by the CYP1A1 promoter - a quantitative study.

Nucleic Acids Res 2015 Jun 23;43(11):5318-30

Schulthess P, Löffler A, Vetter S, Kreft L, Schwarz M, Braeuning A, Blüthgen N

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Analysis of impedance-based cellular growth assays.

Bioinformatics 2015 Apr 21;

Witzel F, Fritsche-Guenther R, Lehmann N, Sieber A, Blüthgen N

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Silence on the relevant literature and errors in implementation.

Nat Biotechnol 2015 Apr;33(4):336-9

Bastiaens P, Birtwistle MR, Blüthgen N, Bruggeman FJ, Cho KH, Cosentino C, de la Fuente A, Hoek JB, Kiyatkin A, Klamt S, Kolch W, Legewie S, Mendes P, Naka T, Santra T, Sontag E, Westerhoff HV, Kholodenko BN

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Gene expression. MicroRNA control of protein expression noise.

Science 2015 Apr 3;348(6230):128-32

Schmiedel JM, Klemm SL, Zheng Y, Sahay A, Blüthgen N, Marks DS, van Oudenaarden A

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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