Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Michiel Vermeulen37 Publications.


Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148.

Nat Commun 2017 May 2;8:15034

Fang J, Jia J, Makowski M, Xu M, Wang Z, Zhang T, Hoskins JW, Choi J, Han Y, Zhang M, Thomas J, Kovacs M, Collins I, Dzyadyk M, Thompson A, O'Neill M, Das S, Lan Q, Koster R, PanScan Consortium., TRICL Consortium., GenoMEL Consortium., Stolzenberg-Solomon RS, Kraft P, Wolpin BM, Jansen PWTC, Olson S, McGlynn KA, Kanetsky PA, Chatterjee N, Barrett JH, Dunning AM, Taylor JC, Newton-Bishop JA, Bishop DT, Andresson T, Petersen GM, Amos CI, Iles MM, Nathanson KL, Landi MT, Vermeulen M, Brown KM, Amundadottir LT

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An Interaction Landscape of Ubiquitin Signaling.

Mol Cell 2017 Mar 2;65(5):941-955.e8

Zhang X, Smits AH, van Tilburg GB, Jansen PW, Makowski MM, Ovaa H, Vermeulen M

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SDHD Promoter Mutations Ablate GABP Transcription Factor Binding in Melanoma.

Cancer Res 2017 Apr 1;77(7):1649-1661

Zhang T, Xu M, Makowski MM, Lee C, Kovacs M, Fang J, Willems E, Trent JM, Hayward NK, Vermeulen M, Brown KM

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Click-MS: Tagless Protein Enrichment Using Bioorthogonal Chemistry for Quantitative Proteomics.

ACS Chem Biol 2016 Oct 17;

Smits AH, Borrmann A, Roosjen M, van Hest JC, Vermeulen M

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ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.

Cell Rep 2016 Oct 11;17(3):783-798

Spruijt CG, Luijsterburg MS, Menafra R, Lindeboom RG, Jansen PW, Edupuganti RR, Baltissen MP, Wiegant WW, Voelker-Albert MC, Matarese F, Mensinga A, Poser I, Vos HR, Stunnenberg HG, van Attikum H, Vermeulen M

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Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex.

Development 2016 Jul 28;

Miller A, Ralser M, Kloet SL, Loos R, Nishinakamura R, Bertone P, Vermeulen M, Hendrich B

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The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation.

Nat Struct Mol Biol 2016 Jun 13;

Kloet SL, Makowski MM, Baymaz HI, van Voorthuijsen L, Karemaker ID, Santanach A, Jansen PW, Di Croce L, Vermeulen M

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Characterizing Protein-Protein Interactions Using Mass Spectrometry: Challenges and Opportunities.

Trends Biotechnol 2016 Mar 17;

Smits AH, Vermeulen M

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Active DNA demethylation at enhancers during the vertebrate phylotypic period.

Nat Genet 2016 Apr;48(4):417-26

Bogdanović O, Smits AH, de la Calle Mustienes E, Tena JJ, Ford E, Williams R, Senanayake U, Schultz MD, Hontelez S, van Kruijsbergen I, Rayon T, Gnerlich F, Carell T, Veenstra GJ, Manzanares M, Sauka-Spengler T, Ecker JR, Vermeulen M, Gómez-Skarmeta JL, Lister R

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Recruitment of the mammalian histone modifying EMSY complex to target genes is regulated by ZNF131.

J Biol Chem 2016 Feb 3;

Varier RA, Carrillo de Santa Pau E, van der Groep P, Lindeboom RG, Matarese F, Mensinga A, Smits AH, Edupuganti RR, Baltissen MP, Jansen PW, Ter Hoeve N, van Weely DR, Poser I, van Diest PJ, Stunnenberg HG, Vermeulen M

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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