Advancing Epigenetics Towards Systems Biology

List of EpiGeneSys publications

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Group Leader:
Florian Markowetz14 Publications.


OncoNEM: inferring tumor evolution from single-cell sequencing data.

Genome Biol 2016 Apr 15;17(1):69

Ross EM, Markowetz F

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Accumulated metabolites of hydroxybutyric acid serve as diagnostic and prognostic biomarkers of high-grade serous ovarian carcinomas.

Cancer Res 2015 Dec 18;

Hilvo M, de Santiago I, Gopalacharyulu P, Schmitt WD, Budczies J, Kuhberg M, Dietel M, Aittokallio T, Markowetz F, Denkert C, Sehouli J, Frezza C, Darb-Esfahani S, Braicu EI

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Regulators of genetic risk of breast cancer identified by integrative network analysis.

Nat Genet 2016 Jan;48(1):12-21

Castro MA, de Santiago I, Campbell TM, Vaughn C, Hickey TE, Ross E, Tilley WD, Markowetz F, Ponder BA, Meyer KB

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You Are Not Working for Me; I Am Working with You.

PLoS Comput Biol 2015 Sep;11(9):e1004387

Markowetz F

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BitPhylogeny: a probabilistic framework for reconstructing intra-tumor phylogenies.

Genome Biol 2015 Feb 13;16(1):36

Yuan K, Sakoparnig T, Markowetz F, Beerenwinkel N

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Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.

PLoS Med 2015 Feb;12(2):e1001789

Schwarz RF, Ng CK, Cooke SL, Newman S, Temple J, Piskorz AM, Gale D, Sayal K, Murtaza M, Baldwin PJ, Rosenfeld N, Earl HM, Sala E, Jimenez-Linan M, Parkinson CA, Markowetz F, Brenton JD

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Combined image and genomic analysis of high-grade serous ovarian cancer reveals PTEN loss as a common driver event and prognostic classifier.

Genome Biol 2014 Dec 17;15(12):526

Martins FC, Santiago Id, Trinh A, Xian J, Guo A, Sayal K, Jimenez-Linan M, Deen S, Driver K, Mack M, Aslop J, Pharoah PD, Markowetz F, Brenton JD

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Cancer evolution: mathematical models and computational inference.

Syst Biol 2014 Oct 7;

Beerenwinkel N, Schwarz RF, Gerstung M, Markowetz F

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SANTA: Quantifying the Functional Content of Molecular Networks.

PLoS Comput Biol 2014 Sep;10(9):e1003808

Cornish AJ, Markowetz F

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GoIFISH: a system for the quantification of single cell heterogeneity from IFISH images.

Genome Biol 2014 Aug 26;15(8):442

Trinh A, Rye IH, Almendro V, Helland A, Russnes HG, Markowetz F

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Latest publications


The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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The impact of rare and low-frequency genetic variants in common disease.

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