An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 141

Zentrum für Molekulare Biologie der Universität Heidelberg, Heidelberg, Germany

Regulators of Centromere Identity and Function

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Our research focuses on the regulation of centromeric chromatin, specifically on the centromere-specific histone-variant CENP-A in Drosophila. CENP-A loading and CENP-A protein amount are highly regulated and require specific control mechanisms. The disturbance of CENP-A localization and levels cause severe chromosome segregation defects and genome instability. We are investigating the precise mechanisms of centromere-specific CENP-A loading and how cells avoid ectopic localization of CENP-A. We have unraveled different loading mechanisms and are currently studying the biological purpose for these processes. We are also investigating how different protein modifications influence loading, centromere identity and CENP-A protein levels. We use Drosophila as a model system and take advantage of its advanced genetic tools, use cell biological and molecular approaches, live cell and high throughput microscopy.

People involved:

  • Veena Mathew (post-doc)
  • Anne-Laure Pauleau (post-doc)
  • Debora Bade (PhD student)
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Latest publications

No longer a nuisance: long non-coding RNAs join CENP-A in epigenetic centromere regulation.

26748759 – 2016-01-11
Cell Mol Life Sci 2016 Jan 9;
Rošić S, Erhardt S

Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division.

25452389 – 2014-12-03
J Cell Biol 2014 Dec 1;
Rošić S, Köhler F, Erhardt S

Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division.

25365994 – 2014-11-05
J Cell Biol 2014 Nov 10;207(3):335-49
Rošić S, Köhler F, Erhardt SView all their publications