Laboratory of Genome Regulation, Boğaziçi University, Istanbul, Turkey
Gene Regulation and Cancer
We study the mechanisms and consequences of cancer-associated changes in gene regulation to understand the disease processes and to identify targets for therapeutic intervention. Previously we have identified the genome-wide targets and cancer-associated funtions of transcription factors and chromatin modifiers that the B-cell cancer cells are ‘addicted' for their survival and proliferation. Currently, we are working on transcription factors with critical roles in melanoma skin cancers in order to uncover the gene regulatory networks controlled by these factors.
Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma.
25359993 – 2014-11-02
Blood 2014 Oct 30;
A Polymorphism in IRF4 Affects Human Pigmentation through a Tyrosinase-Dependent MITF/TFAP2A Pathway.
24267888 – 2013-11-26
Cell 2013 Nov 21;155(5):1022-33
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