An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 151

Miguel A. Peinado

Institute of Predictive and Personalized Medicine of Cancer, Barcelona, Spain

Epigenetic Mechanisms of Cell Differentiation and Cancer

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DNA sequence contributes to set the Epigenome landscape and, in turn, the Epigenome conditions the reading of genetic information. The main goal of our research is to define the genetic and epigenetic determinants of chromatin architecture in cell differentiation and cancer.

In the lab we apply genome-scale strategies to identify and functionally characterize chromatin compartments and their boundaries. Emphasis is made in the separate analysis of different types of genomic elements and how epigenetic signatures are dynamically regulated in different biological and pathological programs .

Our research is framed into three main projects:

  1. Insights into the role of DNA repeats in genome organization and regulation.
  2. Characterization of epigenetic mechanisms during muscle lineage-commitment, cell activation and terminal differentiation.
  3. Clinically oriented research on the epigenetic changes involved in human cancer.

Lab members:

  • Miguel A. Peinado, PI
  • Mònica Suelves, PI
  • Mireia Jordà (Postdoc)
  • Izaskun Mallona (Postdoc, Bioinformatician)
  • Anna Diez (Biostatistician)
  • Mar Muñoz (Technician)
  • Berta Martin (Technician)
  • Joaquin Custodio (PhD student)
  • Elvira Carrió (PhD student)
  • Yaiza Nuñez (PhD student)
  • Raquel Buj (PhD student)