An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 96

The Babraham Institute, Cambridge, United Kingdom

Chromosome structure and functional nuclear organization of the genome

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The spatial organization of the genome inside the cell nucleus is tissue-specific and has been linked to regulation of several nuclear processes including gene activation, gene silencing, genomic imprinting, gene co-regulation, genome maintenance, DNA replication, DNA repair, chromosomal translocations and X chromosome inactivation. In fact, just about any genome function has a spatial component that has been implicated in its control. We know surprisingly little about chromosome conformation and spatial organization or how they are established. However, emerging data indicate that structure and spatial organization are drivers of genome functions, which in cooperation with other features including epigenetic marks, non-coding RNAs and trans-acting factors bring about genome control. We are studying genome function by integrating various genetic and epigenetic features in the context of realistic 3D nuclear architecture.

Pepole:

  • Dr Takashi Nagano
  • Dr Stefan Schoenfelder
  • Dr Mayra Furlan-Magaril
  • Dr Louise Harewood
  • Dr Biola Javierre Martinez
  • Dr Jorg Morf
  • Mr Luke Edelman
  • Mr Andrew Dimond
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Latest publications

HiCUP: pipeline for mapping and processing Hi-C data.

26835000 – 2016-02-03
F1000Res 2015;4:1310
Wingett S, Ewels P, Furlan-Magaril M, Nagano T, Schoenfelder S, Fraser P, Andrews S

Integrated genome-scale analysis of the transcriptional regulatory landscape in a blood stem/progenitor cell model.

26809507 – 2016-01-27
Blood 2016 Jan 25;
Wilson NK, Schoenfelder S, Hannah R, Sánchez Castillo M, Schütte J, Ladopoulos V, Mitchelmore J, Goode DK, Calero-Nieto FJ, Moignard V, Wilkinson AC, Jimenez-Madrid I, Kinston S, Spivakov M, Fraser P, Göttgens B

Ocean acidification boosts larval fish development but reduces the window of opportunity for successful settlement.

26674946 – 2015-12-18
Proc Biol Sci 2015 Dec 22;282(1821)
Rossi T, Nagelkerken I, Simpson SD, Pistevos JC, Watson SA, Merillet L, Fraser P, Munday PL, Connell SDView all their publications

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