An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 171

CeMM Research Center for Molecular Medicine , Vienna, Austria

Medical Epigenomics

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The Bock Lab at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences combines large-scale analysis of the epigenome with molecular biology and computational modeling, in order to better understand and treat leukemia and other diseases of the blood system. The team members work closely with biologists and medical researchers at the Medical University of Vienna, aiming to advance personalized medicine through epigenome sequencing and bioinformatic innovation.

Research Topic
Epigenomics. The lab is part of the BLUEPRINT project aimed at establishing, analyzing and interpreting comprehensive epigenome maps of >100 cell types of the blood and immune system.
Bioinformatics. We develop bioinformatic methods and infrastructure for analyzing DNA methylation data in the context of epigenome-wide association studies.
Diagnostics. Using large-scale DNA methylation mapping, bioinformatic prioritization and functional characterization, we strive to develop clinically relevant biomarkers for informing cancer therapy.

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Latest publications

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.

27159579 – 2016-05-10
Nat Chem Biol 2016 May 9;
Sdelci S, Lardeau CH, Tallant C, Klepsch F, Klaiber B, Bennett J, Rathert P, Schuster M, Penz T, Fedorov O, Superti-Furga G, Bock C, Zuber J, Huber KV, Knapp S, Müller S, Kubicek S

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN.

27149854 – 2016-05-07
Cell Rep 2016 Apr 14;
Mazouzi A, Stukalov A, Müller AC, Chen D, Wiedner M, Prochazkova J, Chiang SC, Schuster M, Breitwieser FP, Pichlmair A, El-Khamisy SF, Bock C, Kralovics R, Colinge J, Bennett KL, Loizou JI

Familial early-onset dementia with complex neuropathologic phenotype and genomic background.

27143436 – 2016-05-05
Neurobiol Aging 2016 Jun;42:199-204
Alexander J, Kalev O, Mehrabian S, Traykov L, Raycheva M, Kanakis D, Drineas P, Lutz MI, Ströbel T, Penz T, Schuster M, Bock C, Ferrer I, Paschou P, Kovacs GGView all their publications

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