An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 137

Institute of Molecular Biology (IMB), Mainz, Germany

Molecular Epigenetics

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The laboratory of Molecular Epigenetics seeks to understand how environmental factors and cellular signals rewrite the epigenetic information that is stored in chromatin and how these alterations are interpreted in the course of DNA repair, embryonic stem cell differentiation and ageing. We are particularly interested in revealing the underlying molecular pathways of the aforementioned cellular processes employing chromatin biochemistry, sophisticated microscopy techniques and next-generation sequencing. Our research interests include:

  1. The involvement of epigenetic components during UV type DNA repair
  2. The role of ncRNAs at the onset of embryonic stem cell differentiation
  3. The dynamics of the epigenetic landscape during ageing

Lab members:

  • Jonathan Byrne
  • Ekaterina Gracheva
  • Thomas Wilhelm
  • Thaleia Papadopoulou
  • Mieun Lee-Theilen
  • Stephanos Papaefstathiou

Latest publications

Dual Role of Med12 in PRC1-dependent Gene Repression and ncRNA-mediated Transcriptional Activation.

27096886 – 2016-04-21
Cell Cycle 2016 Apr 20;:0
Papadopoulou T, Kaymak A, Sayols S, Richly H

ZRF1 mediates remodeling of E3 ligases at DNA lesion sites during nucleotide excision repair.

27091446 – 2016-04-20
J Cell Biol 2016 Apr 25;213(2):185-200
Gracheva E, Chitale S, Wilhelm T, Rapp A, Byrne J, Stadler J, Medina R, Cardoso MC, Richly HView all their publications