Institute of Pathology / Theoretical Biology, Charite - Universitätsmedizin Berlin
Systems Biology of Regulatory Networks
Our group investigates how mammalian cells use molecular networks to process information, and how these networks control cell-fate decisions. We are interested in how the topology of network gives rise to function, how feedbacks help in robust cellular decision-making and regulation of cellular identity. Our research focuses on gene regulatory and signaling networks that control cell growth (EGFR/MAPK) as well as gene regulatory networks involved in cell differentiation, and use perturbation and time series data to derive network models. We are an interdisciplinary team with background in physics, biology, engineering and medical sciences. Consequently, we combine theoretical as well as experimental approaches to dissect these networks.
PhD students involved: Johannes Meisig