Advancing Epigenetics Towards Systems Biology

Peter Fraser

The Babraham Institute, Cambridge, United Kingdom

Chromosome structure and functional nuclear organization of the genome

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peter fraser

 

The spatial organization of the genome inside the cell nucleus is tissue-specific and has been linked to regulation of several nuclear processes including gene activation, gene silencing, genomic imprinting, gene co-regulation, genome maintenance, DNA replication, DNA repair, chromosomal translocations and X chromosome inactivation. In fact, just about any genome function has a spatial component that has been implicated in its control. We know surprisingly little about chromosome conformation and spatial organization or how they are established. However, emerging data indicate that structure and spatial organization are drivers of genome functions, which in cooperation with other features including epigenetic marks, non-coding RNAs and trans-acting factors bring about genome control. We are studying genome function by integrating various genetic and epigenetic features in the context of realistic 3D nuclear architecture.

Pepole:

  • Dr Takashi Nagano
  • Dr Stefan Schoenfelder
  • Dr Mayra Furlan-Magaril
  • Dr Louise Harewood
  • Dr Biola Javierre Martinez
  • Dr Jorg Morf
  • Mr Luke Edelman
  • Mr Andrew Dimond

Latest publications

GOTHiC, a probabilistic model to resolve complex biases and to identify real interactions in Hi-C data.

28379994 - 2017-04-06
PLoS One 2017;12(4):e0174744

Mifsud B, Martincorena I, Darbo E, Sugar R, Schoenfelder S, Fraser P, Luscombe NM

Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.

28332981 - 2017-03-24
Elife 2017 Mar 23;6

Freire-Pritchett P, Schoenfelder S, Várnai C, Wingett SW, Cairns J, Collier AJ, García-Vílchez R, Furlan-Magaril M, Osborne CS, Fraser P, Rugg-Gunn PJ, Spivakov M

HiCUP: pipeline for mapping and processing Hi-C data.

26835000 - 2016-02-03
F1000Res 2015;4:1310

Wingett S, Ewels P, Furlan-Magaril M, Nagano T, Schoenfelder S, Fraser P, Andrews S

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