Advancing Epigenetics Towards Systems Biology

Déborah Bourc'his

Institut Curie, Paris, France

Epigenetic setting of the germline : protecting the genome and building up the future

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deborah bourchisdeborah bourchis group

The process of germ line differentiation allows the production of mature gametes that carry both genetic and epigenetic information. Epigenetic modifications that occur during mammalian germ cell development have immediate effects on gametic identity, genome integrity through the protection against transposable elements, and sex-specific programming. Our current projects are aimed at understanding 1) how DNA methylation patterns are shaped in germ cells, 2) how they prepare the sperm and the egg for the process of fertilization, 3) how they provide the gametes with the potential to promote an entire new organism and faithfully perpetuate the hereditary material and 4) how they can impact on the embryo but also, on a longer term, on the adult individual and eventually, on the next generations. We combine genetic, cellular and developmental approaches with genome-wide and biochemical strategies, and rely on mouse models of deficiency in DNA methylation and other epigenetic modifications.

People :

  • PhD students:
    • Sophie Ajjan
    • Rachel Duffié
    • Marius Walter
  • Post-doc fellows
    • Max Greenberg
    • Natasha Zamudio
  • Assistant Engineer
    • Julian Iranzo

Latest publications

An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells.

26814573 - 2016-01-28
Elife 2016 Jan 27;5

Walter M, Teissandier A, Pérez-Palacios R, Bourc'his D

Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency.

26159833 - 2015-07-15
Reproduction 2015 Oct;150(4):245-56

Liao HF, Mo CF, Wu SC, Cheng DH, Yu CY, Chang KW, Kao TH, Lu CW, Pinskaya M, Morillon A, Lin SS, Cheng WT, Bourc'his D, Bestor T, Sung LY, Lin SP

Erratum: MORC1 represses transposable elements in the mouse male germline.

26159654 - 2015-07-15
Nat Commun 2015 Jul 10;6:7604

Pastor WA, Stroud H, Nee K, Liu W, Pezic D, Manakov S, Lee SA, Moissiard G, Zamudio N, Bourc'his D, Aravin AA, Clark AT, Jacobsen SE

View all their publications