Advancing Epigenetics Towards Systems Biology

Ho-Ryun Chung

Max Planck Institute for Molecular Genetics, Berlin, Germany

Interplay between chromatin modifications and transcription

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Ho-Ryun ChungHo-Ryun Chung group

The genome of eukaryotes is packed into a macromolecular structure called chromatin. The basic repeating unit of chromatin is the nucleosome, which forms by the association of two copies each of the four core histones H2A, H2B, H3 and H4 and 147 base pairs of DNA. Histones can be covalently modified and the histone modification status of a region correlates with the regions¹ function. Our group is interested in the interplay between chromatin and its modifications with the transcriptional process. Using both experimental and computational methods our goal is to unravel the dynamic interactions between different states of RNA Polymerase II with histone modifications, their writers, readers and erasers.

PhD involved in research on EpiGeneSys projects:

Johannes Helmuth ­ computational analysis of interactions between RNA Polymerase II phosphorylation states and histone modifications

PostDocs involved in research on EpiGenesys projects:

Na Li ­ experimental mapping of RNA Polymerase II phosphorylation states

Alisa Fuchs ­ dynamics of histone modifications and RNA Polymerase II phosphorylation states during transcription in Drosophila

Latest publications

High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila.

26431028 - 2015-10-03
Mol Cell 2015 Oct 1;60(1):146-62

Ramírez F, Lingg T, Toscano S, Lam KC, Georgiev P, Chung HR, Lajoie BR, de Wit E, Zhan Y, de Laat W, Dekker J, Manke T, Akhtar A

A link between Sas2-mediated H4 K16 acetylation, chromatin assembly in S-phase by CAF-I and Asf1, and nucleosome assembly by Spt6 during transcription.

26260510 - 2015-08-12
FEMS Yeast Res 2015 Nov;15(7)

Reiter C, Heise F, Chung HR, Ehrenhofer-Murray AE

Chromatin segmentation based on a probabilistic model for read counts explains a large portion of the epigenome.

26206277 - 2015-07-25
Genome Biol 2015 Jul 24;16:151

Mammana A, Chung HR

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