Josep Carreras Leukaemie Research Institute (IJC), Badalona, Spain
Chromatin, Metabolism and Cell Fate
Epigenetic information is written in chromatin. But how exactly do epigenetic mechanisms operate on the molecular level? How do chromatin alterations contribute to cell fate transitions? How does the environment influence these processes?
Studying differentiation and cancer we focus on molecular aspects of epigenetic regulation and genome organization and on the question whether we can translate this knowledge into diagnostic and therapeutic tools for the management of diseases such as leukemia and myelodysplastic syndrome.
Ongoing projects in the lab fall in one or several of three main themes:
- The link between metabolism and epigenetic regulation.
- The regulation and molecular function of histone variants.
- Chromatin as drug target in myelodysplastic syndrome (MDS) and leukemia.