Advancing Epigenetics Towards Systems Biology

Marcus Buschbeck

Josep Carreras Leukaemie Research Institute (IJC), Badalona, Spain

Chromatin, Metabolism and Cell Fate

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marcus buschbeck

Epigenetic information is written in chromatin. But how exactly do epigenetic mechanisms operate on the molecular level? How do chromatin alterations contribute to cell fate transitions? How does the environment influence these processes?

Studying differentiation and cancer we focus on molecular aspects of epigenetic regulation and genome organization and on the question whether we can translate this knowledge into diagnostic and therapeutic tools for the management of diseases such as leukemia and myelodysplastic syndrome.

Ongoing projects in the lab fall in one or several of three main themes:

  • The link between metabolism and epigenetic regulation.
  • The regulation and molecular function of histone variants.
  • Chromatin as drug target in myelodysplastic syndrome (MDS) and leukemia.

Latest publications

A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma.

27074337 - 2016-04-14
Int J Cancer 2016 Apr 13;

Cantariño N, Fernández-Figueras MT, Valero V, Musulén E, Malinverni R, Granada I, Goldie SJ, Martín-Caballero J, Douet J, Forcales SV, Buschbeck M

Barcelona conference on epigenetics and cancer 2015: Coding and non-coding functions of the genome.

26996885 - 2016-03-22
Epigenetics 2016 Jan 2;11(1):95-100

Corujo D, Mas G, Malinverni R, Di Croce L, Buschbeck M

DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression.

26772755 - 2016-01-17
Cancer Res 2016 Jan 15;

Borghesan M, Fusilli C, Rappa F, Panebianco C, Rizzo G, Oben JA, Mazzoccoli G, Faulkes C, Pata I, Agodi A, Rezaee F, Minogue S, Warren A, Peterson A, Sedivy JM, Douet J, Buschbeck M, Cappello F, Mazza T, Pazienza V, Vinciguerra M

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