Advancing Epigenetics Towards Systems Biology

Nathalie Beaujean

INRA (Institut National de la Recherche Agronomique), Jouy en Josas, France

Genome reprogramming during early embryonic development and after nuclear transfer

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nathalie beaujeannathalie beaujean group

Our objective is to better understand genome reprogramming during early embryonic development either after fertilization or after nuclear transfer (the "cloning" procedure). Cloning experiments indeed offer a unique opportunity to understand how the oocyte's environment dictates the reorganization of the introduced nuclei and thereby the transcriptional programs that can have long term consequences.

It is believed that this reprogramming process relies on finely tuned mechanisms of epigenomic regulation. We are therefore studying nuclear architecture remodeling and epigenetic dynamics in fertilized and cloned embryos, using drugs known to modulate the epigenome. This work is performed in two different mammalian systems (murine and bovine).

It should help us to establish what constitutes "good" nuclear organization and to understand how the environment shapes the epigenome.

List of PhDs and postdocs:

  • Delphine DUBE, PhD
  • Anne-Clémence VEILLARD, PhD
  • Maimouna Coura KONE, PhD
  • Barbara PANNEAU, Post-Doc

Latest publications

Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos.

27156679 - 2016-05-10
Theriogenology 2016 Apr 21;

Sepulveda-Rincon LP, Solanas ED, Serrano-Revuelta E, Ruddick L, Maalouf WE, Beaujean N

Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development.

26984997 - 2016-03-18
Biol Reprod 2016 Apr;94(4):95

Koné MC, Fleurot R, Chebrout M, Debey P, Beaujean N, Bonnet-Garnier A

Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome.

26267271 - 2015-08-13
Epigenetics 2015 Oct 3;10(10):931-42

Deuve JL, Bonnet-Garnier A, Beaujean N, Avner P, Morey C

View all their publications